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    AstA Allatostatin A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42947, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AstAprovided by FlyBase
    Official Full Name
    Allatostatin Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015591
    Locus tag
    Dmel_CG13633
    See related
    AllianceGenome:FB:FBgn0015591
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Allatostatin A1; Allatostatin A2; Allatostatin A3; Allatostatin A4; ALLS; AS; ASA; ast; Ast; AST; AST-1; AST-3; AST-4; Ast-A; AST-A; AstA-1; AstA-2; AstA-3; AstA-4; AstA1; AstA2; AstA4; BcDNA:RE16553; CG13633; DAP; DAP-A; Dmel\CG13633; Drm-AST-1; Drm-AST-2; Drm-AST-3; Drm-AST-4; Drm-AST-A; DST-1A; DST-2A; DST-3A; DST-4A
    Summary
    Enables neuropeptide receptor binding activity. Involved in neuropeptide signaling pathway. Located in extracellular space. Is expressed in several structures, including adult neuromere; allatostatin A neuron; ganglia; gut section; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See AstA in Genome Data Viewer
    Location:
    96A20-96A20; 3-85 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24760530..24765071, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20586252..20590793, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tolloid Neighboring gene abnormal spindle Neighboring gene long non-coding RNA:CR45650 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FGLamide Allatostatin genes in Arthropoda: introns early or late? Martínez-Pérez F, et al. Peptides, 2009 Jul. PMID 19551917
    2. Comparative genomic analysis of allatostatin-encoding (Ast) genes in Drosophila species and prediction of regulatory elements by phylogenetic footprinting. Bowser PR, et al. Peptides, 2007 Jan. PMID 17175069
    3. Immunocytochemical localization of Diploptera punctata allatostatin-like peptide in Drosophila melanogaster. Yoon JG, et al. J Comp Neurol, 1995 Dec 18. PMID 8847412
    4. On the Role of the Head Ganglia in Posture and Walking in Insects. Emanuel S, et al. Front Physiol, 2020. PMID 32153430, Free PMC Article
    5. Immunocytochemical analysis of putative allatostatin receptor (DAR-2) distribution in the CNS of larval Drosophila melanogaster. Bowser PR, et al. Peptides, 2005 Jan. PMID 15626507

    See all (158) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data suggest that AstA/AstAR1 acts to coordinate juvenile growth with maturation. Interesting, AstA/AstAR1 is homologous to KISS/GPR54, a ligand-receptor signal required for human puberty, suggesting that an evolutionary conserved neural circuitry controls the onset of maturation.
      Title: AstA Signaling Functions as an Evolutionary Conserved Mechanism Timing Juvenile to Adult Transition.
    2. Midgut-preferential RNA knockdown of the peptide hormones AstA or Dh31 respectively results in decreased or increased adult lifespan. This effect on longevity is apparently correlated with the midgut senescence phenotypes as a result of direct hormone action through both hormone receptors expressed in the enteroblasts or other midgut cell types
      Title: Drosophila Peptide Hormones Allatostatin A and Diuretic Hormone 31 Exhibiting Complementary Gradient Distribution in Posterior Midgut Antagonistically Regulate Midgut Senescence and Adult Lifespan.
    3. Va-A1 neurons terminally differentiate into DH31/AstA-expressing neurons (neuropeptidergic fate I) by virtue of Ubx activity, and Va-A2-A4 neurons terminally differentiate into Capa-expressing neurons
      Title: Segmentally homologous neurons acquire two different terminal neuropeptidergic fates in the Drosophila nervous system.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hormone activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables neuropeptide hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide hormone activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables neuropeptide receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of juvenile hormone biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    allatostatin A
    Names
    AstA-PA
    AstA-PB
    CG13633-PA
    CG13633-PB
    Drostatin-A1
    Drostatin-A3
    Drostatin-A4
    FGLa-type allatostatin
    allatostatin
    allatostatin A-1
    allatostatin Diploptera-type
    allatostatin-A
    allatostatin-A-like
    allatostatin-A4
    drostatin-A2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24760530..24765071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079765.3 → NP_524489.2  allatostatin A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524489.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NB67, Q9VC44
      UniProtKB/TrEMBL
      A0A0B4LHW3
      Related
      FBpp0084119

    2. NM_001300582.1 → NP_001287511.1  allatostatin A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287511.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NB67, Q9VC44
      UniProtKB/TrEMBL
      A0A0B4LHW3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHW3 A0A0B4LHW3
    Q9VC44.1 Q9VC44

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
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