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    eys eyes shut [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3771890, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eysprovided by FlyBase
    Official Full Name
    eyes shutprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031414
    Locus tag
    Dmel_CG33955
    See related
    AllianceGenome:FB:FBgn0031414
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    21A6; CG15388; CG15389; CG33955; CG7245; CT35437; Dmel\CG33955; Eyes Shut; Eys; EYS; mAb 21A6; mAb21A6; MAb21A6; spacemaker; spam; Spam; SPAM
    Summary
    An extracellular matrix structural constituent. Involved in cell morphogenesis; rhabdomere development; and temperature compensation of the circadian clock. Located in several cellular components, including cell surface; extracellular space; and non-motile cilium. Is expressed in adult head; dendritic cap cell; embryonic head sensory system; scolopale rod; and sense organ. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in retinitis pigmentosa 25. Orthologous to human EYS (eyes shut homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eys in Genome Data Viewer
    Location:
    22E1-22E1; 2-6 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2311680..2358944)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2311680..2358944)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rab5 Neighboring gene AXIN1 up-regulated 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spam and the evolution of the fly's eye. Osorio D. Bioessays, 2007 Feb. PMID 17226795
    2. High-speed imaging of light-induced photoreceptor microsaccades in compound eyes. Kemppainen J, et al. Commun Biol, 2022 Mar 3. PMID 35241794, Free PMC Article
    3. Imaging the Drosophila retina: zwitterionic buffers PIPES and HEPES induce morphological artifacts in tissue fixation. Nie J, et al. BMC Dev Biol, 2015 Feb 3. PMID 25645690, Free PMC Article
    4. Preserving cell shape under environmental stress. Cook B, et al. Nature, 2008 Mar 20. PMID 18297055, Free PMC Article
    5. A mosaic of independent innovations involving eyes shut are critical for the evolutionary transition from fused to open rhabdoms. Mahato S, et al. Dev Biol, 2018 Nov 15. PMID 30243673

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our data suggest that O-glucosylation of Eys by Rumi ensures rhabdomere separation by promoting proper Eys folding and stability in a critical time window during the mid-pupal stage.
      Title: The protein O-glucosyltransferase Rumi modifies eyes shut to promote rhabdomere separation in Drosophila.
    2. eys is essential for epithelial lumen formation in the retina.
      Title: The agrin/perlecan-related protein eyes shut is essential for epithelial lumen formation in the Drosophila retina.
    3. Spacemaker, a secreted protein expressed only in the eyes of insects with open rhabdom systems, acts together with Prominin and the cell adhesion molecule Chaoptin to choreograph the partitioning of rhabdomeres into an open system.
      Title: Transforming the architecture of compound eyes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular matrix structural constituent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in temperature compensation of the circadian clock IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eyes shut
    Names
    CG33955-PE
    CG33955-PF
    Eye shut
    agrin-like
    eyeshut
    eys-PE
    eys-PF
    fibropellin
    spacemaker
    spam

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2311680..2358944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032399.3 → NP_001027571.3  eyes shut, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027571.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1F4, Q06PM7, Q400N0, Q6IHY1, Q8MRJ7
      UniProtKB/TrEMBL
      M9PBU9
      Conserved Domains (4) summary
      cd00054
      Location:220 → 256
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:1956 → 2144
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:1549 → 1578
      EGF; EGF-like domain
      pfam02210
      Location:1723 → 1856
      Laminin_G_2; Laminin G domain

    2. NM_001272995.1 → NP_001259924.2  eyes shut, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259924.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1F4, Q06PM7, Q400N0, Q6IHY1, Q8MRJ7
      UniProtKB/TrEMBL
      M9PBU9
      Conserved Domains (4) summary
      cd00054
      Location:220 → 256
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:1956 → 2144
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:1549 → 1578
      EGF; EGF-like domain
      pfam02210
      Location:1723 → 1856
      Laminin_G_2; Laminin G domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A1F4.1 A0A1F4
    M9PBU9 M9PBU9

    Gene LinkOut

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