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    RalGPS Ral GEF with PH domain and SH3 binding motif [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36881, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RalGPSprovided by FlyBase
    Official Full Name
    Ral GEF with PH domain and SH3 binding motifprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034158
    Locus tag
    Dmel_CG5522
    See related
    AllianceGenome:FB:FBgn0034158
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5522; CG55522; Dmel\CG5522; RasGPS
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in positive regulation of epidermal growth factor receptor signaling pathway and positive regulation of stem cell proliferation. Predicted to be active in plasma membrane. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium. Orthologous to human RALGPS1 (Ral GEF with PH domain and SH3 binding motif 1) and RALGPS2 (Ral GEF with PH domain and SH3 binding motif 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RalGPS in Genome Data Viewer
    Location:
    53D8-53D9; 2-80 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16783671..16792472)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12671176..12679977)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Vitamin-K epoxide reductase Neighboring gene resilin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44465

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi. van Dam TJ, et al. Cell Signal, 2009 Nov. PMID 19567266
    2. RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. Nászai M, et al. Elife, 2021 Jun 7. PMID 34096503, Free PMC Article
    3. A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways. Mirey G, et al. Mol Cell Biol, 2003 Feb. PMID 12529414, Free PMC Article
    4. A machine learning approach for identifying novel cell type-specific transcriptional regulators of myogenesis. Busser BW, et al. PLoS Genet, 2012. PMID 22412381, Free PMC Article
    5. Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster. Gonsalves SE, et al. BMC Genomics, 2011 Sep 29. PMID 21958154, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Ral protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ral GEF with PH domain and SH3 binding motif
    Names
    CG5522-PA
    CG5522-PB
    CG5522-PC
    CG5522-PD
    CG5522-PE
    CG5522-PF
    RalGPS-PA
    RalGPS-PB
    RalGPS-PC
    RalGPS-PD
    RalGPS-PE
    RalGPS-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16783671..16792472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166195.2 → NP_725615.1  Ral GEF with PH domain and SH3 binding motif, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725615.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E949
      Related
      FBpp0086180
      Conserved Domains (3) summary
      smart00147
      Location:163 → 400
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:578 → 692
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:578 → 685
      PH; PH domain

    2. NM_137314.3 → NP_611158.1  Ral GEF with PH domain and SH3 binding motif, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611158.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT78
      Related
      FBpp0086179
      Conserved Domains (3) summary
      smart00147
      Location:163 → 400
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:541 → 655
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:541 → 648
      PH; PH domain

    3. NM_166193.2 → NP_725613.1  Ral GEF with PH domain and SH3 binding motif, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E949
      Related
      FBpp0086177
      Conserved Domains (3) summary
      smart00147
      Location:163 → 400
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:578 → 692
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:578 → 685
      PH; PH domain

    4. NM_166196.2 → NP_725616.1  Ral GEF with PH domain and SH3 binding motif, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725616.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT78
      Related
      FBpp0086178
      Conserved Domains (3) summary
      smart00147
      Location:163 → 400
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:541 → 655
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:541 → 648
      PH; PH domain

    5. NM_166194.2 → NP_725614.1  Ral GEF with PH domain and SH3 binding motif, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E949
      Related
      FBpp0086181
      Conserved Domains (3) summary
      smart00147
      Location:163 → 400
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:578 → 692
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:578 → 685
      PH; PH domain

    6. NM_166197.2 → NP_725617.1  Ral GEF with PH domain and SH3 binding motif, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725617.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT78
      Related
      FBpp0086182
      Conserved Domains (3) summary
      smart00147
      Location:163 → 400
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:541 → 655
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:541 → 648
      PH; PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E949 Q0E949
    Q8MT78 Q8MT78
    Q95RX1 Q95RX1

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