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    Mgat4b alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39609, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mgat4bprovided by FlyBase
    Official Full Name
    alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036447
    Locus tag
    Dmel_CG17173
    See related
    AllianceGenome:FB:FBgn0036447
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17173; Dmel\CG17173; dMGAT4-2; Magt4b; MGAT
    Summary
    Predicted to enable alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human MGAT4C (MGAT4 family member C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mgat4b in Genome Data Viewer
    Location:
    70F4-70F4; 3-42 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14767703..14769283, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14760803..14762383, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Trithorax-like Neighboring gene tRNA splicing endonuclease subunit 34 Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase a Neighboring gene myopic Neighboring gene brummer

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor. Miura GI, et al. Development, 2008 Jun. PMID 18434417, Free PMC Article
    2. Microarray analysis of juvenile hormone response in Drosophila melanogaster S2 cells. Willis DK, et al. J Insect Sci, 2010. PMID 20672983, Free PMC Article
    3. Diversity and functions of protein glycosylation in insects. Walski T, et al. Insect Biochem Mol Biol, 2017 Apr. PMID 28232040
    4. A journey into the world of insect lipid metabolism. Toprak U, et al. Arch Insect Biochem Physiol, 2020 Jun. PMID 32335968
    5. Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing. Yamamoto-Hino M, et al. Genes Cells, 2015 Jun. PMID 25940448, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase b
    Names
    CG17173-PA
    Mgat4b-PA
    NP_648721.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14767703..14769283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140464.2 → NP_648721.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase b [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648721.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T440, Q9VUH5
      Related
      FBpp0075451
      Conserved Domains (1) summary
      pfam04666
      Location:30 → 337
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T440 Q8T440
    Q9VUH5 Q9VUH5

    Gene LinkOut

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