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    Rs1 Rs1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44087, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rs1provided by FlyBase
    Official Full Name
    Rs1provided by FlyBase
    Primary source
    FLYBASE:FBgn0021995
    Locus tag
    Dmel_CG2173
    See related
    AllianceGenome:FB:FBgn0021995
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    153844_at; BcDNA:GM05306; cg2173; CG2173; DDX27; Dmel\CG2173; DmRH21; Drs1; l(2)k09514
    Summary
    Predicted to enable RNA helicase activity. Predicted to be active in nucleolus. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human DDX27 (DEAD-box helicase 27). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rs1 in Genome Data Viewer
    Location:
    44B7-44B7; 2-58 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8163564..8167769)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4051069..4055274)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ras-related GTP binding C/D Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene gasz Neighboring gene Mlh1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential gene expression analysis identified determinants of cell fate plasticity during radiation-induced regeneration in Drosophila. Ledru M, et al. PLoS Genet, 2022 Jan. PMID 34990447, Free PMC Article
    2. Absence of X-chromosome dosage compensation in the primordial germ cells of Drosophila embryos. Ota R, et al. Sci Rep, 2021 Mar 1. PMID 33649478, Free PMC Article
    3. The establishment of sexual identity in the Drosophila germline. Casper AL, et al. Development, 2009 Nov. PMID 19855024, Free PMC Article
    4. Germline masculinization by Phf7 in D. melanogaster requires its evolutionarily novel C-terminus and the HP1-family protein HP1D3csd. Yang SY. Sci Rep, 2021 Mar 18. PMID 33737548, Free PMC Article
    5. The Conserved RNA Exonuclease Rexo5 Is Required for 3' End Maturation of 28S rRNA, 5S rRNA, and snoRNAs. Gerstberger S, et al. Cell Rep, 2017 Oct 17. PMID 29045842, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rs1
    Names
    CG2173-PA
    CG2173-PB
    Rs1-PA
    Rs1-PB
    NP_001286188.1
    NP_651970.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8163564..8167769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299259.1 → NP_001286188.1  Rs1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286188.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQN4, Q7KK34
      Conserved Domains (3) summary
      PTZ00424
      Location:148 → 537
      PTZ00424; helicase 45; Provisional
      cd00268
      Location:159 → 364
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:393 → 498
      Helicase_C; Helicase conserved C-terminal domain

    2. NM_143713.3 → NP_651970.1  Rs1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651970.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQN4, Q7KK34
      Related
      FBpp0087865
      Conserved Domains (3) summary
      PTZ00424
      Location:148 → 537
      PTZ00424; helicase 45; Provisional
      cd00268
      Location:159 → 364
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:393 → 498
      Helicase_C; Helicase conserved C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JQN4 Q7JQN4
    Q7KK34 Q7KK34

    Gene LinkOut

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