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    MED10 Mediator complex subunit 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39777, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MED10provided by FlyBase
    Official Full Name
    Mediator complex subunit 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0036581
    Locus tag
    Dmel_CG5057
    See related
    AllianceGenome:FB:FBgn0036581
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD24044; CG5057; dMED10; Dmel\CG5057; dTRAP15; l(3)72Ds; med10; Med10; Nut2
    Summary
    Enables transcription coregulator activity. Involved in regulation of transcription by RNA polymerase II. Part of mediator complex. Is expressed in spermatozoon. Orthologous to human MED10 (mediator complex subunit 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MED10 in Genome Data Viewer
    Location:
    72D10-72D10; 3-44 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16232084..16232777)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16225184..16225877)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene lethal (3) 72Dn Neighboring gene Thioredoxin-related transmembrane protein 3 Neighboring gene Programmed Cell Death 5 Neighboring gene Heat shock protein cognate 20 Neighboring gene lethal (3) 72Dp Neighboring gene lethal (3) 72Dr

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock. Park JM, et al. Mol Cell, 2001 Jul. PMID 11511356
    2. Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Boube M, et al. Genes Dev, 2000 Nov 15. PMID 11090137, Free PMC Article
    3. Sox21b underlies the rapid diversification of a novel male genital structure between Drosophila species. Ridgway AM, et al. Curr Biol, 2024 Mar 11. PMID 38309269
    4. Differential Requirements for Mediator Complex Subunits in Drosophila melanogaster Host Defense Against Fungal and Bacterial Pathogens. Huang C, et al. Front Immunol, 2020. PMID 33746938, Free PMC Article
    5. Identification of genes affecting wing patterning through a loss-of-function mutagenesis screen and characterization of med15 function during wing development. Terriente-Félix A, et al. Genetics, 2010 Jun. PMID 20233856, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mediator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator complex subunit 10
    Names
    CG5057-PB
    CG5057-PC
    MED10-PB
    MED10-PC
    mediator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16232084..16232777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275002.1 → NP_001261931.1  mediator complex subunit 10, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261931.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9GYU7, Q9VUZ9
      UniProtKB/TrEMBL
      M9PFU7
      Conserved Domains (1) summary
      pfam09748
      Location:9 → 127
      Med10; Transcription factor subunit Med10 of Mediator complex

    2. NM_140592.4 → NP_648849.3  mediator complex subunit 10, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648849.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9GYU7, Q9VUZ9
      UniProtKB/TrEMBL
      M9PFU7
      Conserved Domains (1) summary
      pfam09748
      Location:9 → 127
      Med10; Transcription factor subunit Med10 of Mediator complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFU7 M9PFU7
    Q9GYU7.1 Q9GYU7

    Gene LinkOut

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