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    Atg8b Autophagy-related 8b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42132, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atg8bprovided by FlyBase
    Official Full Name
    Autophagy-related 8bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038539
    Locus tag
    Dmel_CG12334
    See related
    AllianceGenome:FB:FBgn0038539
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    atg8; Atg8; ATG8; atg8b; atg8B; Atg8B; ATG8b; ATG8B; CG12334; dAtg8; dAtg8b; Dmel\CG12334
    Summary
    Predicted to enable several functions, including phosphatidylethanolamine binding activity; protein tag activity; and ubiquitin protein ligase binding activity. Involved in macroautophagy. Located in autophagosome. Is expressed in adult heart and organism. Orthologous to human GABARAPL1 (GABA type A receptor associated protein like 1) and GABARAPL3 (GABA type A receptor associated protein like 3 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Atg8b in Genome Data Viewer
    Location:
    90C2-90C2; 3-61 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17724410..17725063, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13550146..13550766, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene osa Neighboring gene long non-coding RNA:CR46035 Neighboring gene Peroxinectin-like Neighboring gene Leucine-rich repeat-containing G protein-coupled receptor 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Atg8 family proteins, LIR/AIM motifs and other interaction modes. Rogov VV, et al. Autophagy Rep, 2023 Dec 31. PMID 38214012, Free PMC Article
    2. Lifespan extension without fertility reduction following dietary addition of the autophagy activator Torin1 in Drosophila melanogaster. Mason JS, et al. PLoS One, 2018. PMID 29329306, Free PMC Article
    3. Autophagic paintings: In the frontier of art and science. Valko A. Autophagy, 2019 Nov. PMID 31455131, Free PMC Article
    4. β-Guanidinopropionic acid extends the lifespan of Drosophila melanogaster via an AMP-activated protein kinase-dependent increase in autophagy. Yang S, et al. Aging Cell, 2015 Dec. PMID 26120775, Free PMC Article
    5. Mitofusin gain and loss of function drive pathogenesis in Drosophila models of CMT2A neuropathy. El Fissi N, et al. EMBO Rep, 2018 Aug. PMID 29898954, Free PMC Article

    See all (120) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The two autophagy-related proteins 8a and 8b play distinct physiological roles in Drosophila.
      Title: The two autophagy-related proteins 8a and 8b play distinct physiological roles in Drosophila.
    2. Analysis of Drosophila Atg8 proteins reveals multiple lipidation-independent roles.
      Title: Analysis of Drosophila Atg8 proteins reveals multiple lipidation-independent roles.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GABA receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tag activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macroautophagy IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Autophagy-related 8b
    Names
    Atg8b-PA
    Atg8b-PB
    CG12334-PA
    CG12334-PB
    autophagy related gene 8
    autophagy-specific gene 8b

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17724410..17725063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316551.1 → NP_001303480.1  Autophagy-related 8b, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEG5
      Conserved Domains (1) summary
      cd01611
      Location:7 → 118
      GABARAP; Ubiquitin domain of GABA-receptor-associated protein

    2. NM_142392.3 → NP_650649.1  Autophagy-related 8b, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650649.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEG5
      Related
      FBpp0082957
      Conserved Domains (1) summary
      cd01611
      Location:7 → 118
      GABARAP; Ubiquitin domain of GABA-receptor-associated protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K1J3 Q7K1J3
    Q9VEG5 Q9VEG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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