U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Spn42Dd Serpin 42Dd [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49808, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Spn42Ddprovided by FlyBase
    Official Full Name
    Serpin 42Ddprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028988
    Locus tag
    Dmel_CG9456
    See related
    AllianceGenome:FB:FBgn0028988
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9456; Dmel\CG9456; sp1; Spn1
    Summary
    Enables serine-type endopeptidase inhibitor activity. Involved in negative regulation of Toll receptor ligand protein activation cascade; negative regulation of antifungal innate immune response; and negative regulation of antimicrobial peptide production. Located in extracellular space. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive nonsyndromic deafness 91; intermediate coronary syndrome; thrombophilia (multiple); thrombosis; and toxic shock syndrome. Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB12 (serpin family B member 12); and SERPINB13 (serpin family B member 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Spn42Dd in Genome Data Viewer
    Location:
    42D6-42D6; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6883280..6884873)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2770785..2772378)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44169 Neighboring gene Serpin 42Da Neighboring gene Serpin 42Db Neighboring gene Serpin 42Dc Neighboring gene Serpin 42De Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A novel Drosophila serpin that inhibits serine proteases. Han J, et al. FEBS Lett, 2000 Feb 25. PMID 10692585
    2. Spn1 regulates the GNBP3-dependent Toll signaling pathway in Drosophila melanogaster. Fullaondo A, et al. Mol Cell Biol, 2011 Jul. PMID 21576362, Free PMC Article
    3. Spatial regulation of developmental signaling by a serpin. Hashimoto C, et al. Dev Cell, 2003 Dec. PMID 14667416
    4. Isoform-specific regulation of a steroid hormone nuclear receptor by an E3 ubiquitin ligase in Drosophila melanogaster. Gradilla AC, et al. Genetics, 2011 Nov. PMID 21900267, Free PMC Article
    5. Assisting Hox proteins in controlling body form: are there new lessons from flies (and mammals)? Mahaffey JW. Curr Opin Genet Dev, 2005 Aug. PMID 15979870

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of Toll receptor ligand protein activation cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Toll receptor ligand protein activation cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of antifungal innate immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of antifungal innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    serpin 42Dd
    Names
    CG9456-PB
    Spn42Dd-PB
    serine protease inhibitor 1
    serpin 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6883280..6884873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169596.3 → NP_001163067.1  serpin 42Dd [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163067.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KA42, Q7YTY6
      Conserved Domains (1) summary
      cd00172
      Location:16 → 369
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YTY6.1 Q7YTY6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous