Strn-Mlck Stretchin-Mlck [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Strn-Mlckprovided by FlyBase
Official Full Name: Stretchin-Mlckprovided by FlyBase
Primary source: FLYBASE:FBgn0265045
Locus tag: Dmel_CG44162
See related: AllianceGenome:FB:FBgn0265045
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 143736_at; A(225); BcDNA:RH74685; BEST:GH22543; CG15699; CG18255; CG44162; CG8304; CT41348; Dmel\CG44162; Mlc-k; mlck; Mlck; MLCK; MLCK-1; MLCK-2; MLCK-3; strn-mlck; Strn-mlck; Strn-MLCK; Strn/Mlck
Old locus tag: Dmel_CG15699; Dmel_CG18255
Summary: Enables calcium/calmodulin-dependent protein kinase activity; cytoskeletal motor activator activity; and myosin light chain kinase activity. Involved in negative regulation of hippo signaling. Located in lateral cell cortex. Is expressed in several structures, including adult brain; adult heart; indirect flight muscle cell; larval muscle system; and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 52D4-52D9; 2-76 cM

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (15946933..15989498, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (11834438..11877003, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results are consistent with a model in which phosphatidylinositol 4,5-bisphosphate hydrolysis acts via Ca2+ to activate myosin via MLCK and thereby control actin dynamics during constriction of the contractile ring.
Title: Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium/calmodulin-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cytoskeletal motor activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables myosin light chain kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables myosin light chain kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables myosin light chain kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in lateral cell cortex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Stretchin-Mlck

Names: 225kD protein; A-band-protein-225; CG44162-PB; CG44162-PG; CG44162-PJ; CG44162-PM; CG44162-PN; CG44162-PR; CG44162-PS; CG44162-PT; CG44162-PU; CG44162-PV; MLC-kinase; Strn-Mlck-PB; Strn-Mlck-PG; Strn-Mlck-PJ; Strn-Mlck-PM; Strn-Mlck-PN; Strn-Mlck-PR; Strn-Mlck-PS; Strn-Mlck-PT; Strn-Mlck-PU; Strn-Mlck-PV; myosin light chain kinase; stretchin; stretchin-klp; stretchin-mlck

NP_001188949.1

EC 2.7.11.1

EC 2.7.11.17

EC 2.7.11.18

NP_001188952.1

EC 2.7.11.1

EC 2.7.11.17

EC 2.7.11.18

NP_001188953.2

EC 2.7.11.1

EC 2.7.11.17

EC 2.7.11.18

NP_001188955.2

EC 2.7.11.1

EC 2.7.11.17

EC 2.7.11.18

NP_001261018.1

EC 2.7.11.1

EC 2.7.11.17

EC 2.7.11.18

NP_001261019.1

EC 2.7.11.1

EC 2.7.11.17

EC 2.7.11.18

NP_523754.2

EC 2.7.11.1

EC 2.7.11.17

EC 2.7.11.18

NP_725509.2

EC 2.7.11.1

EC 2.7.11.17

EC 2.7.11.18

NP_725510.2

EC 2.7.11.1

EC 2.7.11.17

EC 2.7.11.18

NP_725511.2

EC 2.7.11.1

EC 2.7.11.17

EC 2.7.11.18

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

15946933..15989498 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166129.3 → NP_725510.2 Stretchin-Mlck, isoform V [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725510.2

Status: REVIEWED

UniProtKB/TrEMBL

A1ZA72

Conserved Domains (11) summary

cd00096
Location:6459 → 6528

Ig; Immunoglobulin domain

smart00408
Location:6793 → 6858

IGc2; Immunoglobulin C-2 Type

smart00220
Location:7620 → 7876

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:7167 → 7239

IG; Immunoglobulin

smart00410
Location:5412 → 5482

IG_like; Immunoglobulin like

cd00063
Location:7489 → 7588

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:6442 → 6531

I-set; Immunoglobulin I-set domain

cd14103
Location:7626 → 7876

STKc_MLCK; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase

pfam02463
Location:2190 → 2854

SMC_N; RecF/RecN/SMC N terminal domain

pfam13895
Location:244 → 314

Ig_2; Immunoglobulin domain

cl11960
Location:6328 → 6412

Ig; Immunoglobulin domain
NM_001274090.1 → NP_001261019.1 Stretchin-Mlck, isoform U [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261019.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KG35

Conserved Domains (11) summary

cd00096
Location:6459 → 6528

Ig; Immunoglobulin domain

smart00408
Location:6793 → 6858

IGc2; Immunoglobulin C-2 Type

smart00220
Location:7620 → 7876

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:5412 → 5482

IG; Immunoglobulin

smart00410
Location:51 → 127

IG_like; Immunoglobulin like

cd00063
Location:7489 → 7588

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:6442 → 6531

I-set; Immunoglobulin I-set domain

cd14103
Location:7626 → 7876

STKc_MLCK; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase

pfam02463
Location:2190 → 2854

SMC_N; RecF/RecN/SMC N terminal domain

pfam13895
Location:244 → 314

Ig_2; Immunoglobulin domain

cl11960
Location:6328 → 6412

Ig; Immunoglobulin domain
NM_001202026.2 → NP_001188955.2 Stretchin-Mlck, isoform T [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188955.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JD82

Conserved Domains (11) summary

cd00096
Location:6420 → 6489

Ig; Immunoglobulin domain

smart00408
Location:6754 → 6819

IGc2; Immunoglobulin C-2 Type

smart00220
Location:7581 → 7837

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:5373 → 5443

IG; Immunoglobulin

smart00410
Location:7367 → 7436

IG_like; Immunoglobulin like

cd00063
Location:7450 → 7549

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:6403 → 6492

I-set; Immunoglobulin I-set domain

cd14103
Location:7587 → 7837

STKc_MLCK; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase

pfam02463
Location:2151 → 2815

SMC_N; RecF/RecN/SMC N terminal domain

pfam13895
Location:205 → 275

Ig_2; Immunoglobulin domain

cl11960
Location:6289 → 6373

Ig; Immunoglobulin domain
NM_001274089.1 → NP_001261018.1 Stretchin-Mlck, isoform S [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261018.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KF84

Conserved Domains (11) summary

cd00096
Location:6420 → 6489

Ig; Immunoglobulin domain

smart00408
Location:6754 → 6819

IGc2; Immunoglobulin C-2 Type

smart00220
Location:7581 → 7837

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:5373 → 5443

IG; Immunoglobulin

smart00410
Location:7367 → 7436

IG_like; Immunoglobulin like

cd00063
Location:7450 → 7549

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:6403 → 6492

I-set; Immunoglobulin I-set domain

cd14103
Location:7587 → 7837

STKc_MLCK; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase

pfam02463
Location:2151 → 2815

SMC_N; RecF/RecN/SMC N terminal domain

pfam13895
Location:205 → 275

Ig_2; Immunoglobulin domain

cl11960
Location:6289 → 6373

Ig; Immunoglobulin domain
NM_079030.4 → NP_523754.2 Stretchin-Mlck, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523754.2

Status: REVIEWED

UniProtKB/TrEMBL

A1ZA69, O01651

Related

FBpp0307628

Conserved Domains (5) summary

smart00220
Location:294 → 550

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00410
Location:80 → 149

IG_like; Immunoglobulin like

cd00063
Location:163 → 262

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14103
Location:300 → 550

STKc_MLCK; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase

cl11960
Location:66 → 149

Ig; Immunoglobulin domain
NM_001202023.2 → NP_001188952.1 Stretchin-Mlck, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188952.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JD64, D0Z749

Conserved Domains (5) summary

smart00220
Location:278 → 534

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00410
Location:64 → 133

IG_like; Immunoglobulin like

cd00063
Location:147 → 246

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14103
Location:284 → 534

STKc_MLCK; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase

cl11960
Location:50 → 133

Ig; Immunoglobulin domain
NM_001202024.2 → NP_001188953.2 Stretchin-Mlck, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188953.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JCU1, Q9GV81

Conserved Domains (5) summary

smart00220
Location:278 → 534

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00410
Location:64 → 133

IG_like; Immunoglobulin like

cd00063
Location:147 → 246

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14103
Location:284 → 534

STKc_MLCK; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase

cl11960
Location:50 → 133

Ig; Immunoglobulin domain
NM_166128.3 → NP_725509.2 Stretchin-Mlck, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725509.2

Status: REVIEWED

UniProtKB/TrEMBL

A1ZA70, Q9GTV1

Conserved Domains (3) summary

smart00220
Location:150 → 406

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00063
Location:19 → 118

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14103
Location:156 → 406

STKc_MLCK; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase
NM_001202020.1 → NP_001188949.1 Stretchin-Mlck, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188949.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MYR8, Q9GV82

Conserved Domains (5) summary

cd00096
Location:409 → 475

Ig; Immunoglobulin domain

smart00408
Location:29 → 94

IGc2; Immunoglobulin C-2 Type

smart00410
Location:403 → 475

IG_like; Immunoglobulin like

pfam07679
Location:15 → 104

I-set; Immunoglobulin I-set domain

cl11960
Location:174 → 258

Ig; Immunoglobulin domain
NM_166130.2 → NP_725511.2 Stretchin-Mlck, isoform R [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725511.2

Status: REVIEWED

UniProtKB/TrEMBL

A1ZA73

Conserved Domains (5) summary

cd00096
Location:1625 → 1689

Ig; Immunoglobulin domain

smart00408
Location:830 → 895

IGc2; Immunoglobulin C-2 Type

cd00121
Location:524 → 577

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

pfam07679
Location:1345 → 1428

I-set; Immunoglobulin I-set domain

cl11960
Location:1837 → 1910

Ig; Immunoglobulin domain

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4JCU1		A0A0B4JCU1
A0A0B4JD64		A0A0B4JD64
A0A0B4JD82		A0A0B4JD82
A0A0B4KF84		A0A0B4KF84
A0A0B4KG35		A0A0B4KG35
A1ZA69		A1ZA69
A1ZA70		A1ZA70
A1ZA72		A1ZA72
A1ZA73		A1ZA73
O01651		O01651
O01652		O01652
O01653		O01653
Q24205		Q24205
Q8MYR8		Q8MYR8
Q95R30		Q95R30
Q9GTV0		Q9GTV0
Q9GTV1		Q9GTV1
Q9GV79		Q9GV79
Q9GV80		Q9GV80
Q9GV81		Q9GV81
Q9GV82		Q9GV82
Q9N630		Q9N630
Q9N6N9		Q9N6N9
Q9NBA9		Q9NBA9
Q9NBB0		Q9NBB0
Q9NBB1		Q9NBB1
Q9NBB2		Q9NBB2
Q9NBB3		Q9NBB3
Q9NBB4		Q9NBB4
Q9NBB6		Q9NBB6
Q9NBB7		Q9NBB7
Q9NBB8		Q9NBB8
Q9NBB9		Q9NBB9
Q9NBC0		Q9NBC0
Q9NBC1		Q9NBC1
Q9NBC2		Q9NBC2
Q9NBC3		Q9NBC3
Q9NBC4		Q9NBC4
Q9NBC5		Q9NBC5
Q9NBC6		Q9NBC6