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    Mbs Myosin binding subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49070, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mbsprovided by FlyBase
    Official Full Name
    Myosin binding subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005536
    Locus tag
    Dmel_CG32156
    See related
    AllianceGenome:FB:FBgn0005536
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0573/06; 0953/04; CG32156; CG5600; CG5891; DMbs; DMBS; Dmel\CG32156; DMYPT; l(3)03802; l(3)72Dd; l(3)j3B4; l(3)j7A1; l(3)S005331b; l(3)S057306; l(3)S057306b; l(3)S095304; mbs; MBS; Mypt
    Summary
    Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Involved in several processes, including germline ring canal formation; neuron differentiation; and regulation of compound eye photoreceptor development. Located in apical cortex. Colocalizes with apical junction complex. Is expressed in several structures, including embryonic/larval esophageal visceral muscle; female germline cyst; germarium; larval muscle cell; and larval muscle system. Orthologous to several human genes including PPP1R12B (protein phosphatase 1 regulatory subunit 12B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mbs in Genome Data Viewer
    Location:
    72D1-72D1; 3-44 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16051959..16082026)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16045059..16075126)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45889 Neighboring gene Death-associated inhibitor of apoptosis 1 Neighboring gene long non-coding RNA:CR43951 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Taspase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Contractile and mechanical properties of epithelia with perturbed actomyosin dynamics. Fischer SC, et al. PLoS One, 2014. PMID 24759936, Free PMC Article
    2. Myosin light-chain phosphatase regulates basal actomyosin oscillations during morphogenesis. Valencia-Expósito A, et al. Nat Commun, 2016 Feb 18. PMID 26888436, Free PMC Article
    3. Structural Redundancy in Supracellular Actomyosin Networks Enables Robust Tissue Folding. Yevick HG, et al. Dev Cell, 2019 Sep 9. PMID 31353314, Free PMC Article
    4. Integration of actomyosin contractility with cell-cell adhesion during dorsal closure. Duque J, et al. Development, 2016 Dec 15. PMID 27836966
    5. Tissue Fluidity Promotes Epithelial Wound Healing. Tetley RJ, et al. Nat Phys, 2019 Jul 4. PMID 31700525, Free PMC Article

    See all (131) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mbs regulates not only Myosin phosphorylation but also adhesion dynamics through control of Moesin phosphorylation, showing that Mbs coordinates actomyosin contractility with cell-cell adhesion during amnioserosa morphogenesis.
      Title: Integration of actomyosin contractility with cell-cell adhesion during dorsal closure.
    2. Par-1 binds to myosin phosphatase and phosphorylates it at a known inactivating site. Par-1 thus promotes phosphorylated myosin regulatory light chain, thereby increasing Myo-II activity.
      Title: Par-1 controls myosin-II activity through myosin phosphatase to regulate border cell migration.
    3. Mutations of DMYPT cause over constriction of contractile rings and ring canals during Drosophila germline cyst formation
      Title: Mutations of DMYPT cause over constriction of contractile rings and ring canals during Drosophila germline cyst formation.
    4. The requirement of DMBS for the integrity of static epithelial cells in imaginal discs suggests that the regulation of Myosin II by DMBS has a role more general than its previously demonstrated functions in morphogenetic events.
      Title: Essential roles of myosin phosphatase in the maintenance of epithelial cell integrity of Drosophila imaginal disc cells.
    5. required for cell sheet movement during dorsal closure, morphogenesis of the eye, and ring canal growth during oogenesis
      Title: Roles of myosin phosphatase during Drosophila development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germline ring canal formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing hair organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of compound eye photoreceptor development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with apical cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with apical junction complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin binding subunit
    Names
    CG32156-PE
    CG32156-PF
    CG32156-PG
    CG32156-PH
    CG32156-PI
    CG32156-PJ
    CG32156-PK
    CG32156-PL
    CG32156-PM
    CG32156-PN
    CG32156-PO
    CG32156-PP
    CG32156-PQ
    CG32156-PR
    CG32156-PS
    CG32156-PT
    CG32156-PU
    CG32156-PV
    MLC-phosphatase
    Mbs-PE
    Mbs-PF
    Mbs-PG
    Mbs-PH
    Mbs-PI
    Mbs-PJ
    Mbs-PK
    Mbs-PL
    Mbs-PM
    Mbs-PN
    Mbs-PO
    Mbs-PP
    Mbs-PQ
    Mbs-PR
    Mbs-PS
    Mbs-PT
    Mbs-PU
    Mbs-PV
    lethal (3) S057306b
    lethal (3) S095304
    lethal(3)72Dd
    myosin phosphatase
    myosin phosphatase target subunit
    myosin phosphatase-binding subunit
    myosin-binding subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16051959..16082026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259856.2 → NP_001246785.1  myosin binding subunit, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246785.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDS8, Q8MT32
      Conserved Domains (4) summary
      cd00204
      Location:50 → 164
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:53 → 142
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:1178 → 1244
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:78 → 109
      ANK; ANK repeat [structural motif]

    2. NM_001259857.2 → NP_001246786.1  myosin binding subunit, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246786.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEB2, Q8MT32
      Conserved Domains (4) summary
      cd00204
      Location:50 → 164
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:53 → 142
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:1177 → 1272
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:78 → 109
      ANK; ANK repeat [structural motif]

    3. NM_001259855.2 → NP_001246784.1  myosin binding subunit, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFF6, Q8MT32
      Conserved Domains (4) summary
      cd00204
      Location:50 → 164
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:53 → 142
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:1176 → 1242
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:78 → 109
      ANK; ANK repeat [structural motif]

    4. NM_168647.3 → NP_730100.2  myosin binding subunit, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730100.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86R99, Q9VUX6
      Conserved Domains (4) summary
      cd00204
      Location:50 → 164
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:53 → 142
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:793 → 859
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:78 → 109
      ANK; ANK repeat [structural motif]

    5. NM_001104144.3 → NP_001097614.1  myosin binding subunit, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNT5, Q86R99
      Conserved Domains (4) summary
      cd00204
      Location:50 → 164
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:53 → 142
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:728 → 794
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:78 → 109
      ANK; ANK repeat [structural motif]

    6. NM_001104145.3 → NP_001097615.1  myosin binding subunit, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097615.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNT4, Q86RA0
      Conserved Domains (4) summary
      cd00204
      Location:50 → 164
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:53 → 142
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:858 → 924
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:78 → 109
      ANK; ANK repeat [structural motif]

    7. NM_168646.3 → NP_730099.2  myosin binding subunit, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730099.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQN4, Q8MT32
      Conserved Domains (4) summary
      cd00204
      Location:50 → 164
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:53 → 142
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:1048 → 1143
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:78 → 109
      ANK; ANK repeat [structural motif]

    8. NM_168648.3 → NP_730101.2  myosin binding subunit, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730101.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT32, Q8MV37
      Conserved Domains (4) summary
      cd00204
      Location:50 → 164
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:53 → 142
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:1005 → 1100
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:78 → 109
      ANK; ANK repeat [structural motif]

    9. NM_001259854.2 → NP_001246783.1  myosin binding subunit, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246783.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDA1, Q8MT32
      Conserved Domains (4) summary
      cd00204
      Location:50 → 164
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:53 → 142
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:1134 → 1229
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:78 → 109
      ANK; ANK repeat [structural motif]

    10. NM_001259858.2 → NP_001246787.1  myosin binding subunit, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246787.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFZ0
      Conserved Domains (3) summary
      cd00204
      Location:50 → 164
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:53 → 142
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:78 → 109
      ANK; ANK repeat [structural motif]

    11. NM_001274990.1 → NP_001261919.1  myosin binding subunit, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261919.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCQ3, Q8MT32
      Conserved Domains (4) summary
      cd00204
      Location:50 → 164
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:53 → 142
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:1005 → 1100
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:78 → 109
      ANK; ANK repeat [structural motif]

    12. NM_001382059.1 → NP_001369057.1  myosin binding subunit, isoform V [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q6S9, Q8MT32
      Conserved Domains (4) summary
      PHA03095
      Location:48 → 282
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:78 → 109
      ANK; ANK repeat [structural motif]
      pfam15898
      Location:1005 → 1071
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cd21930
      Location:430 → 476
      IPD_PPP1R12; inhibitory phosphorylation domain of protein phosphatase 1 regulatory subunit 12 (PPP1R12) family

    13. NM_001382055.1 → NP_001369053.1  myosin binding subunit, isoform R [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q913
      Conserved Domains (1) summary
      pfam15898
      Location:426 → 521
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    14. NM_001382057.1 → NP_001369055.1  myosin binding subunit, isoform T [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3QGN9
      Conserved Domains (1) summary
      pfam15898
      Location:426 → 492
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    15. NM_001104143.3 → NP_001097613.1  myosin binding subunit, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNT6
      Conserved Domains (1) summary
      pfam15898
      Location:271 → 366
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    16. NM_001382058.1 → NP_001369056.1  myosin binding subunit, isoform U [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q790
      Conserved Domains (1) summary
      pfam15898
      Location:271 → 337
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    17. NM_001382056.1 → NP_001369054.1  myosin binding subunit, isoform S [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q7U2
      Conserved Domains (1) summary
      pfam15898
      Location:426 → 521
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    18. NM_140573.6 → NP_648830.1  myosin binding subunit, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648830.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUX7
      Related
      FBpp0075199
      Conserved Domains (1) summary
      pfam15898
      Location:271 → 366
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6M3Q6S9 A0A6M3Q6S9
    A0A6M3Q790 A0A6M3Q790
    A0A6M3Q7U2 A0A6M3Q7U2
    A0A6M3Q913 A0A6M3Q913
    A0A6M3QGN9 A0A6M3QGN9
    A8JNT4 A8JNT4
    A8JNT5 A8JNT5
    A8JNT6 A8JNT6
    M9NDA1 M9NDA1
    M9NDS8 M9NDS8
    M9NEB2 M9NEB2
    M9NFF6 M9NFF6
    M9NFZ0 M9NFZ0
    M9PCQ3 M9PCQ3
    Q86R99 Q86R99
    Q86RA0 Q86RA0
    Q8IQN4 Q8IQN4
    Q8MT32 Q8MT32
    Q8MV37 Q8MV37
    Q95SD5 Q95SD5
    Q9VUX6 Q9VUX6
    Q9VUX7 Q9VUX7

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