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    MED7 Mediator complex subunit 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41288, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MED7provided by FlyBase
    Official Full Name
    Mediator complex subunit 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0051390
    Locus tag
    Dmel_CG31390
    See related
    AllianceGenome:FB:FBgn0051390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31390; CG6529; dMED7; Dmel\CG31390; dTRAP34; Med7
    Summary
    Enables transcription coregulator activity. Involved in regulation of transcription by RNA polymerase II. Predicted to be part of core mediator complex and mediator complex. Is expressed in organism. Orthologous to human MED7 (mediator complex subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MED7 in Genome Data Viewer
    Location:
    86C5-86C5; 3-50 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10760071..10761032, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6585793..6586754, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45015 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45016 Neighboring gene Chromosome associated protein H2 Neighboring gene Transcription factor TFIIFbeta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth. Guo L, et al. Nucleic Acids Res, 2016 Sep 19. PMID 27207882, Free PMC Article
    2. Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics. Gomez-Lamarca MJ, et al. Dev Cell, 2018 Mar 12. PMID 29478922, Free PMC Article
    3. Transcription regulation and animal diversity. Levine M, et al. Nature, 2003 Jul 10. PMID 12853946
    4. Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock. Park JM, et al. Mol Cell, 2001 Jul. PMID 11511356
    5. Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Boube M, et al. Genes Dev, 2000 Nov 15. PMID 11090137, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mediator complex subunit 7
    Names
    CG31390-PA
    MED7-PA
    mediator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10760071..10761032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169357.2 → NP_731500.1  mediator complex subunit 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731500.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0JQ36, Q9GYV9
      Related
      FBpp0081787
      Conserved Domains (1) summary
      pfam05983
      Location:8 → 166
      Med7; MED7 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GYV9.1 Q9GYV9

    Gene LinkOut

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