U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Nepl16 Neprilysin-like 16 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43014, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Nepl16provided by FlyBase
    Official Full Name
    Neprilysin-like 16provided by FlyBase
    Primary source
    FLYBASE:FBgn0039277
    Locus tag
    Dmel_CG13650
    See related
    AllianceGenome:FB:FBgn0039277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13650; Dmel\CG13650
    Summary
    Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Nepl16 in Genome Data Viewer
    Location:
    96C1-96C1; 3-87 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25109226..25112516, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20934948..20938238, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tubulin tyrosine ligase-like 5 Neighboring gene uncharacterized protein Neighboring gene vig2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    2. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    3. Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC). Borrás T, et al. Genetics, 2003 Feb. PMID 12618402, Free PMC Article
    4. Differential gene expression related to Nora virus infection of Drosophila melanogaster. Cordes EJ, et al. Virus Res, 2013 Aug. PMID 23603562, Free PMC Article
    5. Active promoters and insulators are marked by the centrosomal protein 190. Bartkuhn M, et al. EMBO J, 2009 Apr 8. PMID 19229299, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Neprilysin-like 16
    Names
    CG13650-PB
    Nepl16-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25109226..25112516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104442.2 → NP_001097912.1  Neprilysin-like 16 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097912.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NR63, Q9VBX6
      Conserved Domains (1) summary
      cl14813
      Location:176 → 749
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NR63 Q6NR63
    Q9VBX6 Q9VBX6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous