Nup50 Nucleoporin 50kD [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nup50provided by FlyBase
Official Full Name: Nucleoporin 50kDprovided by FlyBase
Primary source: FLYBASE:FBgn0033264
Locus tag: Dmel_CG2158
See related: AllianceGenome:FB:FBgn0033264
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2158; Dmel\CG2158; Nup; nup50; NUP50
Summary: Enables chromatin DNA binding activity. Involved in heat shock-mediated polytene chromosome puffing; positive regulation of transcription by RNA polymerase II; and protein import into nucleus. Located in chromatin and polytene chromosome band. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; head epidermis primordium; mesoderm; and visceral mesoderm derivative. Used to study neurodegenerative disease. Orthologous to human NUP50 (nucleoporin 50). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8123036..8125058)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4010541..4012563)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables chromatin DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in heat shock-mediated polytene chromosome puffing	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
located_in polytene chromosome band	IDA Inferred from Direct Assay more info	PubMed

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