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    Nnf1a Nnf1a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37325, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nnf1aprovided by FlyBase
    Official Full Name
    Nnf1aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034523
    Locus tag
    Dmel_CG13434
    See related
    AllianceGenome:FB:FBgn0034523
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13434; Dmel\CG13434; dmNnf1R-2
    Summary
    Enables kinetochore adaptor activity. Involved in attachment of spindle microtubules to kinetochore and mitotic metaphase chromosome alignment. Located in kinetochore. Part of MIS12/MIND type complex. Is expressed in several structures, including antennal primordium; central brain primordium; ganglia; head epidermis primordium; and nephrocyte. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nnf1a in Genome Data Viewer
    Location:
    57A6-57A6; 2-91 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20586222..20587238, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16473727..16474743, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mir-991 stem loop Neighboring gene mir-992 stem loop Neighboring gene Heterogeneous nuclear ribonucleoprotein K Neighboring gene mir-7 stem loop Neighboring gene Hillarin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Nnf1 paralogs are partially redundant for somatic and germ line kinetochore function. Blattner AC, et al. Chromosoma, 2017 Feb. PMID 26892014
    2. Network of protein interactions within the Drosophila inner kinetochore. Richter MM, et al. Open Biol, 2016 Feb. PMID 26911623, Free PMC Article
    3. Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster. Liu Y, et al. Open Biol, 2016 Feb. PMID 26911624, Free PMC Article
    4. Adaptive evolution of newly emerged micro-RNA genes in Drosophila. Lu J, et al. Mol Biol Evol, 2008 May. PMID 18296702, Free PMC Article
    5. Kinetochore Proteins Have a Post-Mitotic Function in Neurodevelopment. Zhao G, et al. Dev Cell, 2019 Mar 25. PMID 30827899, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables kinetochore adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome alignment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MIS12/MIND type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nnf1a
    Names
    CG13434-PA
    Nnf1-related protein 2
    Nnf1a-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20586222..20587238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137648.4 → NP_611492.1  Nnf1a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611492.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JZC9
      Related
      FBpp0085569
      Conserved Domains (1) summary
      PHA02562
      Location:124 → 194
      46; endonuclease subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JZC9 Q7JZC9

    Gene LinkOut

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