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    Tsp29Fb Tetraspanin 29Fb [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34212, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsp29Fbprovided by FlyBase
    Official Full Name
    Tetraspanin 29Fbprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032075
    Locus tag
    Dmel_CG9496
    See related
    AllianceGenome:FB:FBgn0032075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:ParkEST130; CG9496; Dm.Tsp29Fb; Dmel\CG9496
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 58. Orthologous to human CD63 (CD63 molecule); TSPAN6 (tetraspanin 6); and TSPAN7 (tetraspanin 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp29Fb in Genome Data Viewer
    Location:
    29F5-29F5; 2-34 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8937390..8939743)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8937390..8939743)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46071 Neighboring gene Tetraspanin 29Fa Neighboring gene Argininosuccinate lyase Neighboring gene uncharacterized protein Neighboring gene Core 1 Galactosyltransferase A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer. Zoranovic T, et al. PLoS Genet, 2018 Oct. PMID 30325918, Free PMC Article
    2. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. Seigneuret M, et al. J Biol Chem, 2001 Oct 26. PMID 11483611
    3. Molecular Basis for Cephalic Mechanosensitivity of Drosophila Larvae. Zhang Z, et al. Neurosci Bull, 2020 Sep. PMID 32761438, Free PMC Article
    4. Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging. Huang J, et al. PNAS Nexus, 2023 Dec. PMID 38059264, Free PMC Article
    5. Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. Jeibmann A, et al. J Neurooncol, 2015 Sep. PMID 26224160

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin 29Fb
    Names
    CG9496-PA
    CG9496-PB
    CG9496-PC
    Tsp29Fb-PA
    Tsp29Fb-PB
    Tsp29Fb-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8937390..8939743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144337.2 → NP_001137809.1  tetraspanin 29Fb, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLH0
      Conserved Domains (2) summary
      cd03127
      Location:110 → 218
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:14 → 246
      Tetraspannin; Tetraspanin family

    2. NM_164838.2 → NP_723426.1  tetraspanin 29Fb, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723426.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLH0
      Related
      FBpp0079357
      Conserved Domains (2) summary
      cd03127
      Location:110 → 218
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:14 → 246
      Tetraspannin; Tetraspanin family

    3. NM_078792.3 → NP_523516.1  tetraspanin 29Fb, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523516.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLH0
      Related
      FBpp0079356
      Conserved Domains (2) summary
      cd03127
      Location:110 → 218
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:14 → 246
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLH0 Q9VLH0

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