alka alkaliphile [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: alkaprovided by FlyBase
Official Full Name: alkaliphileprovided by FlyBase
Primary source: FLYBASE:FBgn0033558
Locus tag: Dmel_CG12344
See related: AllianceGenome:FB:FBgn0033558
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12344; CT23391; Dmel\CG12344; Lcch-47C
Summary: Enables pH-gated chloride channel activity and taste receptor activity. Involved in several processes, including cellular response to alkaline pH; chloride transmembrane transport; and negative regulation of neuronal action potential. Is active in plasma membrane. Is expressed in adult labial sensory neurons; labellum; prothoracic leg taste bristle chemosensory neurons; and sense organ. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (10827430..10835709, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (6714935..6723214, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables glycine-gated chloride ion channel activity	TAS Traceable Author Statement more info	PubMed
enables pH-gated chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables taste receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to alkaline pH	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of taste	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, glycinergic	IGI Inferred from Genetic Interaction more info	PubMed