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    ver verrocchio [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39432, updated on 9-Dec-2024

    Summary

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    Official Symbol
    verprovided by FlyBase
    Official Full Name
    verrocchioprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262524
    Locus tag
    Dmel_CG14121
    See related
    AllianceGenome:FB:FBgn0262524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1479/10; anon-WO0172774.86; anon-WO0172774.87; anon-WO0172774.89; CG14121; Dmel\CG14121; l(3)S147910; Ver
    Summary
    Contributes to single-stranded telomeric DNA binding activity. Involved in telomere capping. Part of telomere cap complex. Is expressed in wing disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ver in Genome Data Viewer
    Location:
    69C4-69C4; 3-38 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12523987..12525150)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12517087..12518250)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene sticky Neighboring gene long non-coding RNA:CR45168 Neighboring gene trailer hitch Neighboring gene Gcn5 acetyltransferase Neighboring gene eukaryotic translation initiation factor 2 subunit beta Neighboring gene nesthocker Neighboring gene Transferrin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Atomic Force Microscopy Reveals that the Drosophila Telomere-Capping Protein Verrocchio Is a Single-Stranded DNA-Binding Protein. Cicconi A, et al. Methods Mol Biol, 2021. PMID 33847963
    2. On the origin of the eukaryotic chromosome: the role of noncanonical DNA structures in telomere evolution. Garavís M, et al. Genome Biol Evol, 2013. PMID 23699225, Free PMC Article
    3. Transposon control mechanisms in telomere biology. Kordyukova M, et al. Curr Opin Genet Dev, 2018 Apr. PMID 29571043
    4. Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex. Raffa GD, et al. Genes Dev, 2010 Aug 1. PMID 20679394, Free PMC Article
    5. If the cap fits, wear it: an overview of telomeric structures over evolution. Fulcher N, et al. Cell Mol Life Sci, 2014 Mar. PMID 24042202, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Evolutionary mode for the functional preservation of fast-evolving Drosophila telomere capping proteins.
      Title: Evolutionary mode for the functional preservation of fast-evolving Drosophila telomere capping proteins.
    2. Atomic Force Microscopy Reveals that the Drosophila Telomere-Capping Protein Verrocchio Is a Single-Stranded DNA-Binding Protein.
      Title: Atomic Force Microscopy Reveals that the Drosophila Telomere-Capping Protein Verrocchio Is a Single-Stranded DNA-Binding Protein.
    3. Ver binds telomeric single-stranded DNA
      Title: The Drosophila telomere-capping protein Verrocchio binds single-stranded DNA and protects telomeres from DNA damage response.
    4. Here we discover a novel protein, Tea, that is specifically enriched at telomeres to prevent telomere fusion. We also identify a complex consisting of Tea and two known capping proteins, Ver and Moi. The Moi-Tea-Ver (MTV) complex purified in vitro binds and protects ssDNA in a sequence-independent manner.
      Title: MTV, an ssDNA Protecting Complex Essential for Transposon-Based Telomere Maintenance in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to single-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in telomere capping IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in telomere capping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of telomere cap complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    verrocchio
    Names
    CG14121-PA
    CG14121-PB
    lethal (3) S147910
    ver-PA
    ver-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12523987..12525150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140330.2 → NP_648587.1  verrocchio, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648587.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VTZ2
      Related
      FBpp0075692

    2. NM_001274848.1 → NP_001261777.1  verrocchio, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261777.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VTZ2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTZ2 Q9VTZ2

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