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    ITP Ion transport peptide [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37921, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ITPprovided by FlyBase
    Official Full Name
    Ion transport peptideprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035023
    Locus tag
    Dmel_CG13586
    See related
    AllianceGenome:FB:FBgn0035023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD05282; CG13586; chgh; CHH-like; Dmel\CG13586; Drm-ITP; DrmITP; DrmITPL1; DrmITPL2; itp; Itp
    Summary
    Predicted to enable neuropeptide hormone activity. Involved in several processes, including locomotor rhythm; multicellular organismal-level water homeostasis; and neuropeptide signaling pathway. Predicted to be located in extracellular space. Is expressed in several structures, including ITP neuron; glial cell; nerve; neurohemal organ; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ITP in Genome Data Viewer
    Location:
    60D4-60D5; 2-107 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24537421..24558961)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20424944..20446484)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nucleosome remodeling factor - 38kD Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The thirsty fly: Ion transport peptide (ITP) is a novel endocrine regulator of water homeostasis in Drosophila. Gáliková M, et al. PLoS Genet, 2018 Aug. PMID 30138334, Free PMC Article
    2. Insect ion transport peptides are derived from alternatively spliced genes and differentially expressed in the central and peripheral nervous system. Dircksen H. J Exp Biol, 2009 Feb. PMID 19151215
    3. Ion transport peptide splice forms in central and peripheral neurons throughout postembryogenesis of Drosophila melanogaster. Dircksen H, et al. J Comp Neurol, 2008 Jul 1. PMID 18418898
    4. Ion transport peptide regulates energy intake, expenditure, and metabolic homeostasis in Drosophila. Gáliková M, et al. Genetics, 2022 Nov 30. PMID 36190340, Free PMC Article
    5. Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila. Zandawala M, et al. Cell Mol Life Sci, 2018 Mar. PMID 29043393, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel antidiuretic hormone governs tumour-induced renal dysfunction.
      Title: A novel antidiuretic hormone governs tumour-induced renal dysfunction.
    2. ITP responds to both osmotic and desiccation stress, and dysregulation of ITP signaling compromises the fly's ability to cope with these stressors.
      Title: The thirsty fly: Ion transport peptide (ITP) is a novel endocrine regulator of water homeostasis in Drosophila.
    3. This study demonistrated that the ion transport peptide is a new functional clock neuropeptide in the fruit fly Drosophila melanogaster.
      Title: The ion transport peptide is a new functional clock neuropeptide in the fruit fly Drosophila melanogaster.
    4. This paper describes the identification of three itp alternative splice forms and the biochemical identification of their corresponding ITPL1, ITPL2 and ITP neuropeptide isoforms.
      Title: Ion transport peptide splice forms in central and peripheral neurons throughout postembryogenesis of Drosophila melanogaster.
    5. We have demonstrated here that subsets of Drosophila lateral clock neurons are heterogeneous with respect to expression of neuroactive compounds, including ion transport peptide and short neuropeptide F
      Title: Peptidergic clock neurons in Drosophila: ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hormone activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables neuropeptide hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide hormone activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in circadian sleep/wake cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in drinking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organismal-level water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of eating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to desiccation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Ion transport peptide
    Names
    CG13586-PC
    CG13586-PD
    CG13586-PE
    CG13586-PF
    CG13586-PG
    ION TRANSPORT PEPTIDE
    ITP-PC
    ITP-PD
    ITP-PE
    ITP-PF
    ITP-PG
    ion transport polypeptide

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24537421..24558961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299916.1 → NP_001286845.1  Ion transport peptide, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286845.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SV5, Q9W151
      Conserved Domains (1) summary
      pfam01147
      Location:37 → 103
      Crust_neurohorm; Crustacean CHH/MIH/GIH neurohormone family

    2. NM_138087.6 → NP_611931.3  Ion transport peptide, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611931.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SV5, Q9W151
      Conserved Domains (1) summary
      pfam01147
      Location:37 → 103
      Crust_neurohorm; Crustacean CHH/MIH/GIH neurohormone family

    3. NM_001169822.3 → NP_001163293.1  Ion transport peptide, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163293.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGW3
      Conserved Domains (1) summary
      pfam01147
      Location:37 → 101
      Crust_neurohorm; Crustacean CHH/MIH/GIH neurohormone family

    4. NM_001043104.3 → NP_001036569.2  Ion transport peptide, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036569.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8W5
      Conserved Domains (1) summary
      pfam01147
      Location:37 → 104
      Crust_neurohorm; Crustacean CHH/MIH/GIH neurohormone family

    5. NM_001169823.2 → NP_001163294.1  Ion transport peptide, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163294.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SV5, Q9W151
      Conserved Domains (1) summary
      pfam01147
      Location:37 → 103
      Crust_neurohorm; Crustacean CHH/MIH/GIH neurohormone family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JGW3 E1JGW3
    Q0E8W5 Q0E8W5
    Q9W151 Q9W151

    Gene LinkOut

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