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    CG17754 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31873, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17754provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030114
    Locus tag
    Dmel_CG17754
    See related
    AllianceGenome:FB:FBgn0030114
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LP02641; Dmel\CG17754
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in amnioserosa; organism; and yolk nucleus. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to several human genes including KLHL5 (kelch like family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17754 in Genome Data Viewer
    Location:
    8D3-8D3; 1-27 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9250420..9255953)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9144453..9149986)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene La related protein 7 Neighboring gene almondex Neighboring gene Downstream of raf1 Neighboring gene ric8a Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins. Wang H, et al. Nat Cell Biol, 2005 Nov. PMID 16228012
    2. Differential gene expression by RNA-seq during Alzheimer's disease-like progression in the Drosophila melanogaster model. da Costa Silva JR, et al. Neurosci Res, 2022 Jul. PMID 35219723
    3. Germline-dependent gene expression in distant non-gonadal somatic tissues of Drosophila. Parisi MJ, et al. BMC Genomics, 2010 Jun 1. PMID 20515475, Free PMC Article
    4. Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model. Park JE, et al. Exp Mol Med, 2023 Jul. PMID 37464094, Free PMC Article
    5. Signalling pathways involved in adult heart formation revealed by gene expression profiling in Drosophila. Zeitouni B, et al. PLoS Genet, 2007 Oct. PMID 17937502, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17754-PA
    CG17754-PC
    CG17754-PD
    CG17754-PE
    CG17754-PF
    CG17754-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9250420..9255953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298118.1 → NP_001285047.1  uncharacterized protein Dmel_CG17754, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285047.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHR5, X2JE93
      Conserved Domains (6) summary
      smart00612
      Location:464 → 510
      Kelch; Kelch domain
      PHA03098
      Location:71 → 591
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:406 → 449
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:70 → 170
      BTB; BTB/POZ domain
      pfam01344
      Location:499 → 546
      Kelch_1; Kelch motif
      pfam07707
      Location:179 → 281
      BACK; BTB And C-terminal Kelch

    2. NM_001298117.1 → NP_001285046.1  uncharacterized protein Dmel_CG17754, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285046.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHR5, Q86BQ6
      Conserved Domains (2) summary
      PHA03098
      Location:71 → 591
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:406 → 449
      Kelch; KELCH repeat [structural motif]

    3. NM_132321.4 → NP_572549.2  uncharacterized protein Dmel_CG17754, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572549.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHR5, Q7K0L2
      Conserved Domains (6) summary
      smart00612
      Location:464 → 510
      Kelch; Kelch domain
      PHA03098
      Location:71 → 591
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:406 → 449
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:70 → 170
      BTB; BTB/POZ domain
      pfam01344
      Location:499 → 546
      Kelch_1; Kelch motif
      pfam07707
      Location:179 → 281
      BACK; BTB And C-terminal Kelch

    4. NM_167187.2 → NP_727331.1  uncharacterized protein Dmel_CG17754, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727331.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHR5, Q7K0L2
      Related
      FBpp0071249
      Conserved Domains (6) summary
      smart00612
      Location:464 → 510
      Kelch; Kelch domain
      PHA03098
      Location:71 → 591
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:406 → 449
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:70 → 170
      BTB; BTB/POZ domain
      pfam01344
      Location:499 → 546
      Kelch_1; Kelch motif
      pfam07707
      Location:179 → 281
      BACK; BTB And C-terminal Kelch

    5. NM_176721.2 → NP_788894.1  uncharacterized protein Dmel_CG17754, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788894.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHR5, Q86BQ6
      Related
      FBpp0071250
      Conserved Domains (2) summary
      PHA03098
      Location:71 → 591
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:406 → 449
      Kelch; KELCH repeat [structural motif]

    6. NM_001298116.1 → NP_001285045.1  uncharacterized protein Dmel_CG17754, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285045.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHR5, X2JD28
      Conserved Domains (5) summary
      smart00612
      Location:360 → 406
      Kelch; Kelch domain
      sd00038
      Location:302 → 345
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:1 → 66
      BTB; BTB/POZ domain
      pfam01344
      Location:395 → 442
      Kelch_1; Kelch motif
      pfam07707
      Location:75 → 177
      BACK; BTB And C-terminal Kelch
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K0L2 Q7K0L2
    Q86BQ6 Q86BQ6
    Q95TT9 Q95TT9
    X2JD28 X2JD28
    X2JE93 X2JE93

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