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    Snm1 Snm1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40669, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snm1provided by FlyBase
    Official Full Name
    Snm1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037338
    Locus tag
    Dmel_CG10018
    See related
    AllianceGenome:FB:FBgn0037338
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10018; Dmel\CG10018; mus322; SNM1
    Summary
    Predicted to enable 5'-3' DNA exonuclease activity and damaged DNA binding activity. Predicted to be involved in double-strand break repair via nonhomologous end joining and interstrand cross-link repair. Is expressed in organism and spermatozoon. Orthologous to human DCLRE1A (DNA cross-link repair 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Snm1 in Genome Data Viewer
    Location:
    83B1-83B2; 3-47.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5555084..5557786)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1380806..1383508)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene meiosis I arrest Neighboring gene Protein-L-isoaspartate (D-aspartate) O-methyltransferase Neighboring gene Phosphatidylinositol 4-kinase II alpha Neighboring gene ncRNA Neighboring gene antisense RNA:CR46136

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A large-scale screen for mutagen-sensitive loci in Drosophila. Laurencon A, et al. Genetics, 2004 May. PMID 15166149, Free PMC Article
    2. DNA Repair in Drosophila: Mutagens, Models, and Missing Genes. Sekelsky J. Genetics, 2017 Feb. PMID 28154196, Free PMC Article
    3. The Adaptive Significance of Natural Genetic Variation in the DNA Damage Response of Drosophila melanogaster. Svetec N, et al. PLoS Genet, 2016 Mar. PMID 26950216, Free PMC Article
    4. A genetic screen and transcript profiling reveal a shared regulatory program for Drosophila linker histone H1 and chromatin remodeler CHD1. Kavi H, et al. G3 (Bethesda), 2015 Jan 27. PMID 25628309, Free PMC Article
    5. Protein interaction mapping: a Drosophila case study. Formstecher E, et al. Genome Res, 2005 Mar. PMID 15710747, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-3' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Snm1
    Names
    CG10018-PA
    Snm1-PA
    mutagen-sensitive 322

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5555084..5557786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141291.4 → NP_649548.1  Snm1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649548.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VND2
      Related
      FBpp0078337
      Conserved Domains (2) summary
      pfam07522
      Location:481 → 578
      DRMBL; DNA repair metallo-beta-lactamase
      cd16273
      Location:252 → 408
      SNM1A-1C-like_MBL-fold; SNM1A , artemis/SNM1C, yeast Pso2p, and related proteins; MBL-fold metallo-hydrolase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VND2 Q9VND2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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