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    rhea rhea [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38978, updated on 9-Dec-2024

    Summary

    Official Symbol
    rheaprovided by FlyBase
    Official Full Name
    rheaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260442
    Locus tag
    Dmel_CG6831
    See related
    AllianceGenome:FB:FBgn0260442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6831; CT21159; Dmel\CG6831; Rhea; talin; Talin; tendrils; Tln
    Old locus tag
    CG6831
    Summary
    Enables integrin binding activity. Involved in several processes, including apposition of dorsal and ventral imaginal disc-derived wing surfaces; border follicle cell migration; and germ-band shortening. Located in focal adhesion. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval midgut primordium; and muscle attachment site. Orthologous to several human genes including TLN2 (talin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See rhea in Genome Data Viewer
    Location:
    66D6-66D7; 3-26 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8545001..8574409)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8538101..8567509)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene fear-of-intimacy Neighboring gene ergic53 Neighboring gene long non-coding RNA:CR43910 Neighboring gene mir-190 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Negative elongation factor E Neighboring gene Ribosomal protein L14

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle cell-cardiac muscle cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in germ-band shortening IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in larval somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lumen formation, open tracheal system HMP PubMed 
    involved_in maintenance of epithelial integrity, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in terminal branching, open tracheal system HMP PubMed 
    Component Evidence Code Pubs
    located_in Z disc HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rhea
    Names
    CG6831-PB
    CG6831-PC
    CG6831-PD
    CG6831-PE
    CG6831-PF
    CG6831-PG
    CG6831-PH
    CG6831-PI
    rhea-PB
    rhea-PC
    rhea-PD
    rhea-PE
    rhea-PF
    rhea-PG
    rhea-PH
    rhea-PI
    talin
    tendrils

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8545001..8574409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259745.2NP_001246674.1  rhea, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246674.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSL8
      Conserved Domains (12) summary
      cd12150
      Location:16611832
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:89322
      B41; Band 4.1 homologues
      COG0840
      Location:16942005
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd10569
      Location:318409
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:215322
      FERM_M; FERM central domain
      pfam01044
      Location:8741035
      Vinculin; Vinculin family
      pfam01608
      Location:23922534
      I_LWEQ; I/LWEQ domain
      pfam08913
      Location:18591982
      VBS; Vinculin Binding Site
      pfam09141
      Location:510668
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92147
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:686778
      I_LWEQ; I/LWEQ domain
    2. NM_001274658.1NP_001261587.1  rhea, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261587.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBW9
      Conserved Domains (12) summary
      cd12150
      Location:16401811
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:89322
      B41; Band 4.1 homologues
      COG0840
      Location:16731984
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd10569
      Location:318409
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:215322
      FERM_M; FERM central domain
      pfam01044
      Location:8531014
      Vinculin; Vinculin family
      pfam01608
      Location:23712513
      I_LWEQ; I/LWEQ domain
      pfam08913
      Location:18381961
      VBS; Vinculin Binding Site
      pfam09141
      Location:489647
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92147
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:665757
      I_LWEQ; I/LWEQ domain
    3. NM_001259746.2NP_001246675.1  rhea, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246675.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDM3
      Conserved Domains (11) summary
      cd12150
      Location:16611832
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:89322
      B41; Band 4.1 homologues
      COG0840
      Location:16942005
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd10569
      Location:318409
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:215322
      FERM_M; FERM central domain
      pfam01044
      Location:8741035
      Vinculin; Vinculin family
      pfam08913
      Location:18591982
      VBS; Vinculin Binding Site
      pfam09141
      Location:510668
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92147
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:686778
      I_LWEQ; I/LWEQ domain
    4. NM_001274659.1NP_001261588.1  rhea, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261588.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEJ8
      Conserved Domains (12) summary
      cd12150
      Location:16611832
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:89322
      B41; Band 4.1 homologues
      COG0840
      Location:16942005
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd10569
      Location:318409
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:215322
      FERM_M; FERM central domain
      pfam01044
      Location:8741035
      Vinculin; Vinculin family
      pfam01608
      Location:23922534
      I_LWEQ; I/LWEQ domain
      pfam08913
      Location:18591982
      VBS; Vinculin Binding Site
      pfam09141
      Location:510668
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92147
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:686778
      I_LWEQ; I/LWEQ domain
    5. NM_001274660.1NP_001261589.1  rhea, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261589.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF06
      Conserved Domains (5) summary
      smart00295
      Location:89322
      B41; Band 4.1 homologues
      cd10569
      Location:318409
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:215322
      FERM_M; FERM central domain
      pfam09379
      Location:92147
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
    6. NM_001259747.2NP_001246676.1  rhea, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246676.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDM3
      Conserved Domains (11) summary
      cd12150
      Location:16611832
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:89322
      B41; Band 4.1 homologues
      COG0840
      Location:16942005
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd10569
      Location:318409
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:215322
      FERM_M; FERM central domain
      pfam01044
      Location:8741035
      Vinculin; Vinculin family
      pfam08913
      Location:18591982
      VBS; Vinculin Binding Site
      pfam09141
      Location:510668
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92147
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:686778
      I_LWEQ; I/LWEQ domain
    7. NM_001274657.1NP_001261586.1  rhea, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261586.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSL8
      Conserved Domains (12) summary
      cd12150
      Location:16611832
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:89322
      B41; Band 4.1 homologues
      COG0840
      Location:16942005
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd10569
      Location:318409
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:215322
      FERM_M; FERM central domain
      pfam01044
      Location:8741035
      Vinculin; Vinculin family
      pfam01608
      Location:23922534
      I_LWEQ; I/LWEQ domain
      pfam08913
      Location:18591982
      VBS; Vinculin Binding Site
      pfam09141
      Location:510668
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92147
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:686778
      I_LWEQ; I/LWEQ domain
    8. NM_139981.4NP_648238.1  rhea, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648238.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSL8
      Related
      FBpp0305318
      Conserved Domains (12) summary
      cd12150
      Location:16611832
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:89322
      B41; Band 4.1 homologues
      COG0840
      Location:16942005
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd10569
      Location:318409
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:215322
      FERM_M; FERM central domain
      pfam01044
      Location:8741035
      Vinculin; Vinculin family
      pfam01608
      Location:23922534
      I_LWEQ; I/LWEQ domain
      pfam08913
      Location:18591982
      VBS; Vinculin Binding Site
      pfam09141
      Location:510668
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92147
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:686778
      I_LWEQ; I/LWEQ domain