Syt7 Synaptotagmin 7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Syt7provided by FlyBase
Official Full Name: Synaptotagmin 7provided by FlyBase
Primary source: FLYBASE:FBgn0039900
Locus tag: Dmel_CG2381
See related: AllianceGenome:FB:FBgn0039900
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10322; CG2381; Dmel\CG2381; dsyt7; Syt 7; Syt VII; syt-7; syt7; SYT7
Summary: Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Involved in regulation of synaptic vesicle exocytosis. Located in sarcoplasm and vesicle. Is active in neuromuscular junction and synaptic membrane. Colocalizes with lysosome. Is expressed in adult head. Orthologous to human SYT7 (synaptotagmin 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 102B3-102B3; 4-0 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (278685..306481, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (299311..327107, complement)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synaptotagmin 7 switches short-term synaptic plasticity from depression to facilitation by suppressing synaptic transmission.
Title: Synaptotagmin 7 switches short-term synaptic plasticity from depression to facilitation by suppressing synaptic transmission.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c289529-282778 mobile_element_type = transposon:rooA{}1496
Loc: c290791-290131 mobile_element_type = transposon:Cr1a{}1497
Loc: c295728-294645 mobile_element_type = transposon:1360{}1498
Loc: c298160-297738 mobile_element_type = transposon:Tc1{}1500
Loc: c304509-304244 mobile_element_type = transposon:INE-1{}5342

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion sensor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium-dependent activation of synaptic vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of calcium ion-dependent exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle exocytosis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synaptic vesicle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: synaptotagmin 7

Names: CG2381-PA; CG2381-PB; CG2381-PF; CG2381-PI; CG2381-PM; Syt7-PA; Syt7-PB; Syt7-PF; Syt7-PI; Syt7-PM; synaptotagmin VII

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004353.4 Reference assembly

Range

278685..306481 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166749.2 → NP_726558.2 synaptotagmin 7, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726558.2

Status: REVIEWED

UniProtKB/TrEMBL

Q6NNV2

Related

FBpp0088202

Conserved Domains (2) summary

cd08386
Location:147 → 271

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cl14603
Location:277 → 326

C2; C2 domain
NM_001258488.2 → NP_001245417.1 synaptotagmin 7, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245417.1

Status: REVIEWED

UniProtKB/TrEMBL

H9XVN2

Conserved Domains (2) summary

cd08386
Location:147 → 271

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cl14603
Location:278 → 312

C2; C2 domain
NM_166748.5 → NP_726557.3 synaptotagmin 7, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726557.3

Status: REVIEWED

UniProtKB/TrEMBL

A4V157, Q9V4C4

Conserved Domains (2) summary

cd08386
Location:147 → 271

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:277 → 414

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
NM_166751.6 → NP_726560.5 synaptotagmin 7, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726560.5

Status: REVIEWED

UniProtKB/TrEMBL

A4V157, Q9V4C4

Conserved Domains (2) summary

cd08386
Location:147 → 271

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:277 → 414

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
NM_205871.3 → NP_995593.2 synaptotagmin 7, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995593.2

Status: REVIEWED

UniProtKB/TrEMBL

Q59DP7

Conserved Domains (2) summary

cd08386
Location:14 → 138

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:144 → 281

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7