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    Rbp1 RNA-binding protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41294, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbp1provided by FlyBase
    Official Full Name
    RNA-binding protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0260944
    Locus tag
    Dmel_CG17136
    See related
    AllianceGenome:FB:FBgn0260944
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17136; Dmel\CG17136; Rbp-1; rbp1; RBP1; Rbp11; Rbp1D; rrm1; RRM1; rrm11; RRM11; SRSF3
    Summary
    Enables mRNA binding activity. Involved in mRNA cis splicing, via spliceosome and regulation of RNA metabolic process. Located in euchromatin and nucleus. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human SRSF3 (serine and arginine rich splicing factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rbp1 in Genome Data Viewer
    Location:
    86C6-86C6; 3-50 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10784383..10786465)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6610105..6612187)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L37 Neighboring gene Arginine methyltransferase 1 Neighboring gene Minichromosome maintenance 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila RNA-binding protein RBP1 is localized to transcriptionally active sites of chromosomes and shows a functional similarity to human splicing factor ASF/SF2. Kim YJ, et al. Genes Dev, 1992 Dec. PMID 1340470
    2. Activation and repression functions of an SR splicing regulator depend on exonic versus intronic-binding position. Shen M, et al. Nucleic Acids Res, 2012 Jan. PMID 21914724, Free PMC Article
    3. The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences. Heinrichs V, et al. EMBO J, 1995 Aug 15. PMID 7664738, Free PMC Article
    4. DX16 is a novel SR protein phosphorylated by DOA. Wan Y, et al. Mol Cell Biochem, 2008 Jan. PMID 17828581
    5. The doublesex splicing enhancer components Tra2 and Rbp1 also repress splicing through an intronic silencer. Qi J, et al. Mol Cell Biol, 2007 Jan. PMID 17101798, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The splicing factors proteins SF2 and RBP1 regulate triglyceride storage in the fat body of Drosophila.
      Title: The SR proteins SF2 and RBP1 regulate triglyceride storage in the fat body of Drosophila.
    2. Rbp1 negatively autoregulates and crossregulates at the level of alternative 3' splice site selection.
      Title: Negative feedback regulation among SR splicing factors encoded by Rbp1 and Rbp1-like in Drosophila.
    3. Rbp1 and Tra2 bind to the ISS independently through distinct sequences suggesting that functionally synergistic interactions of these SR factors can cause either splicing activation or repression.
      Title: The doublesex splicing enhancer components Tra2 and Rbp1 also repress splicing through an intronic silencer.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcriptional start site selection at RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-binding protein 1
    Names
    CG17136-PA
    CG17136-PD
    RNA-binding protein 11
    Rbp1-PA
    Rbp1-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10784383..10786465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169364.3 → NP_731510.1  RNA-binding protein 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731510.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2P0, Q02427, Q26271, Q26280, Q8T9K6, Q9VGW8
      Related
      FBpp0081754
      Conserved Domains (1) summary
      cd12373
      Location:12 → 81
      RRM_SRSF3_like; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins

    2. NM_079583.3 → NP_524307.1  RNA-binding protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524307.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1B2AJY5
      Related
      FBpp0081752
      Conserved Domains (1) summary
      cd12373
      Location:12 → 81
      RRM_SRSF3_like; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02427.3 Q02427

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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