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    C1GalTA Core 1 Galactosyltransferase A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34215, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C1GalTAprovided by FlyBase
    Official Full Name
    Core 1 Galactosyltransferase Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032078
    Locus tag
    Dmel_CG9520
    See related
    AllianceGenome:FB:FBgn0032078
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0144478.18; C1beta3GalT1; C1GalT1; C1GALT1; CG9520; dC1beta3GalT1; dC1GalT; dC1GalT1; Dmel\CG9520
    Summary
    Enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity; manganese ion binding activity; and protein homodimerization activity. Involved in several processes, including central nervous system morphogenesis; negative regulation of hematopoietic stem cell differentiation; and regulation of filopodium assembly. Predicted to be located in membrane. Is expressed in several structures, including brain; embryonic/larval hemocyte; epithelium; gonad; and imaginal disc. Used to study autoimmune disease of blood. Orthologous to human C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See C1GalTA in Genome Data Viewer
    Location:
    29F5-29F5; 2-34 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8943455..8951216, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8943455..8951216, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Tetraspanin 29Fb Neighboring gene Argininosuccinate lyase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis for the synthesis of the core 1 structure by C1GalT1. González-Ramírez AM, et al. Nat Commun, 2022 May 3. PMID 35504880, Free PMC Article
    2. Mucin-type core 1 glycans regulate the localization of neuromuscular junctions and establishment of muscle cell architecture in Drosophila. Itoh K, et al. Dev Biol, 2016 Apr 1. PMID 26896591
    3. Engineering of sialylated mucin-type O-glycosylation in plants. Castilho A, et al. J Biol Chem, 2012 Oct 19. PMID 22948156, Free PMC Article
    4. Extrinsic Functions of Lectin Domains in O-N-Acetylgalactosamine Glycan Biosynthesis. Lorenz V, et al. J Biol Chem, 2016 Dec 2. PMID 27738109, Free PMC Article
    5. Identification of the Drosophila core 1 beta1,3-galactosyltransferase gene that synthesizes T antigen in the embryonic central nervous system and hemocytes. Yoshida H, et al. Glycobiology, 2008 Dec. PMID 18824562

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. T3lec, but not T2lec and T4lec, had a clear activating effect on Drosophila melanogaster core 1 galactosyltransferase enzyme activity
      Title: Extrinsic Functions of Lectin Domains in O-N-Acetylgalactosamine Glycan Biosynthesis.
    2. Lectin staining and blotting experiments confirmed that core 1 galactosyltransferase contributes to the synthesis of Gal-beta1,3-GalNAc in vivo
      Title: Requirement for a core 1 galactosyltransferase in the Drosophila nervous system.
    3. named the CG9520 gene Drosophila core 1 beta1,3-galactosyltransferase 1 because it is responsible for the synthesis and function of T antigen in vivo.
      Title: Identification of the Drosophila core 1 beta1,3-galactosyltransferase gene that synthesizes T antigen in the embryonic central nervous system and hemocytes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-1,3-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in central nervous system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    core 1 galactosyltransferase A
    Names
    C1GalTA-PA
    C1GalTA-PB
    C1GalTA-PC
    CG9520-PA
    CG9520-PB
    CG9520-PC
    core 1 beta1,3-galactosyltransferase
    NP_609258.1
    NP_723427.1
    NP_723428.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8943455..8951216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164840.2 → NP_723428.1  core 1 galactosyltransferase A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723428.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0G7, Q7K237
      UniProtKB/TrEMBL
      E2QCQ7
      Related
      FBpp0079389
      Conserved Domains (1) summary
      cl21608
      Location:119 → 265
      Galactosyl_T; Galactosyltransferase

    2. NM_135414.3 → NP_609258.1  core 1 galactosyltransferase A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609258.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0G7, Q7K237
      UniProtKB/TrEMBL
      E2QCQ7
      Related
      FBpp0079388
      Conserved Domains (1) summary
      cl21608
      Location:119 → 265
      Galactosyl_T; Galactosyltransferase

    3. NM_164839.2 → NP_723427.1  core 1 galactosyltransferase A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723427.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0G7, Q7K237
      UniProtKB/TrEMBL
      E2QCQ7
      Related
      FBpp0079390
      Conserved Domains (1) summary
      cl21608
      Location:119 → 265
      Galactosyl_T; Galactosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QCQ7 E2QCQ7
    Q7K237.1 Q7K237

    Gene LinkOut

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