chrb charybde [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: chrbprovided by FlyBase
Official Full Name: charybdeprovided by FlyBase
Primary source: FLYBASE:FBgn0036165
Locus tag: Dmel_CG7533
See related: AllianceGenome:FB:FBgn0036165
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Liang-2.51; BcDNA:GH09771; CG7533; char; Charybde; Charybdis; Chrb; clone 2.51; Dmel\CG7533; EP(3)1035
Summary: Involved in several processes, including head involution; regulation of TOR signaling; and response to oxidative stress. Predicted to be located in cytoplasm. Is expressed in several structures, including adult brain cell body rind; adult neuromere; anlage in statu nascendi; brain; and visceral mesoderm derivative. Orthologous to human DDIT4 (DNA damage inducible transcript 4) and DDIT4L (DNA damage inducible transcript 4 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (11487550..11499055)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (11480650..11492155)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

scylla and charybdis are induced under hypoxic conditions and that scylla is a target of Drosophila HIF-1
Title: The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila.
scyl and chrb gene products are links between patterning and cell death.
Title: scylla and charybde, homologues of the human apoptotic gene RTP801, are required for head involution in Drosophila.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info