tna tonalli [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tnaprovided by FlyBase
Official Full Name: tonalliprovided by FlyBase
Primary source: FLYBASE:FBgn0026160
Locus tag: Dmel_CG7958
See related: AllianceGenome:FB:FBgn0026160
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0583/02; anon-WO0118547.590; CG7958; Dmel\CG7958; l(3)L6731; l(3)rI075; l(3)S058302; tnaA
Summary: Predicted to enable SUMO ligase activity and nuclear receptor coactivator activity. Involved in transcription initiation-coupled chromatin remodeling. Located in chromatin. Is expressed in several structures, including central brain anlage; central brain primordium; ganglia; ventral ectoderm; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 67F1-67F1; 3-33 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (10835528..10876496)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (10850989..10869596)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TnaA physically interacts with the SUMO E2 conjugating enzyme Ubc9, and with the BRM complex subunit Osa.
Title: TnaA, an SP-RING protein, interacts with Osa, a subunit of the chromatin remodeling complex BRAHMA and with the SUMOylation pathway in Drosophila melanogaster.
Data show that tonalli is involved in postranslational modification of transcription complexes and interacts with Brahma.
Title: The Drosophila trithorax group gene tonalli (tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables SUMO ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables SUMO transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation-coupled chromatin remodeling	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tonalli

Names: CG7958-PA; CG7958-PB; CG7958-PD; CG7958-PE; tna-PA; tna-PB; tna-PD; tna-PE; tonalli A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

10835528..10876496

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001382194.1 → NP_001368945.1 tonalli, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6J3SHB9, D0Z745

Conserved Domains (2) summary

pfam09606
Location:216 → 604

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd16791
Location:792 → 839

SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
NM_140155.4 → NP_648412.2 tonalli, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648412.2

Status: REVIEWED

UniProtKB/TrEMBL

D0Z745, Q9VTB8

Conserved Domains (2) summary

pfam02891
Location:740 → 788

zf-MIZ; MIZ/SP-RING zinc finger

cl09930
Location:370 → 437

RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
NM_001169942.2 → NP_001163413.1 tonalli, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163413.1

Status: REVIEWED

UniProtKB/TrEMBL

D0Z745, Q7JR52

Conserved Domains (2) summary

pfam02891
Location:714 → 762

zf-MIZ; MIZ/SP-RING zinc finger

cl09930
Location:344 → 411

RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
NM_168422.3 → NP_729629.2 tonalli, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729629.2

Status: REVIEWED

UniProtKB/TrEMBL

D0Z745, Q7KUE4

Conserved Domains (2) summary

pfam02891
Location:754 → 802

zf-MIZ; MIZ/SP-RING zinc finger

cl09930
Location:384 → 451

RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.