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    Orc1 Origin recognition complex subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35686, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Orc1provided by FlyBase
    Official Full Name
    Origin recognition complex subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0286788
    Locus tag
    Dmel_CG10667
    See related
    AllianceGenome:FB:FBgn0286788
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10667; Dmel\CG10667; DmOrc1; DmORC1; DmOrc1p; dORC1; fs(2)SC46; ORC; orc1; ORC1; rDmORC; sat
    Summary
    Predicted to enable DNA replication origin binding activity. Involved in DNA amplification and DNA replication initiation. Located in nucleus. Part of nuclear origin of replication recognition complex. Is expressed in several structures, including embryonic/larval midgut primordium; eye disc posterior to the morphogenetic furrow; ganglia; nurse cell; and ventral furrow. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Orc1 in Genome Data Viewer
    Location:
    43D1-43D2; 2-56 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7522437..7525716, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3409942..3413221, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class G Neighboring gene Death resistor Adh domain containing target Neighboring gene long non-coding RNA:CR44209

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The origin recognition complex requires chromatin tethering by a hypervariable intrinsically disordered region that is functionally conserved from sponge to man. Adiji OA, et al. Nucleic Acids Res, 2024 May 8. PMID 38381902, Free PMC Article
    2. Detection of orphan domains in Drosophila using "hydrophobic cluster analysis". Bitard-Feildel T, et al. Biochimie, 2015 Dec. PMID 25736992
    3. An orc1 allele with a mutated APC motif is female sterile with amplification defects. Park SY, et al. Cell Cycle, 2012 Aug 1. PMID 22801552
    4. The 'ORC cycle': a novel pathway for regulating eukaryotic DNA replication. DePamphilis ML. Gene, 2003 May 22. PMID 12801628
    5. Single particle EM studies of the Drosophila melanogaster origin recognition complex and evidence for DNA wrapping. Clarey MG, et al. J Struct Biol, 2008 Dec. PMID 18824234, Free PMC Article

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA amplification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear origin of replication recognition complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    origin recognition complex subunit 1
    Names
    CG10667-PA
    Orc1-PA
    origin recognition complex 1
    satin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7522437..7525716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057955.4 → NP_477303.1  origin recognition complex subunit 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477303.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16810, Q9V4N1
      Related
      FBpp0088033
      Conserved Domains (4) summary
      smart00382
      Location:591 → 741
      AAA; ATPases associated with a variety of cellular activities
      smart01074
      Location:837 → 917
      Cdc6_C; CDC6, C terminal
      cd04719
      Location:44 → 185
      BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
      pfam00004
      Location:594 → 739
      AAA; ATPase family associated with various cellular activities (AAA)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16810.2 O16810

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