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    Daao2 D-amino acid oxidase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33955, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Daao2provided by FlyBase
    Official Full Name
    D-amino acid oxidase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0031860
    Locus tag
    Dmel_CG11236
    See related
    AllianceGenome:FB:FBgn0031860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11236; daao; DAAO; DDO; Dmel\CG11236
    Summary
    Predicted to enable D-amino-acid oxidase activity. Predicted to be involved in D-amino acid catabolic process. Predicted to be located in peroxisome. Predicted to be active in cytoplasm. Is expressed in adult head; adult heart; embryonic midgut chamber; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human DAO (D-amino acid oxidase) and DDO (D-aspartate oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Daao2 in Genome Data Viewer
    Location:
    27B3-27B3; 2-22 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6803011..6804372)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6803011..6804372)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44081 Neighboring gene senseless-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of D-amino acids on sleep in Drosophila. Nakagawa H, et al. Biochem Biophys Res Commun, 2022 Jan 22. PMID 34922200
    2. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Dai X, et al. Nat Commun, 2019 May 7. PMID 31064979, Free PMC Article
    3. Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Heinrichsen ET, et al. Mol Metab, 2014 Feb. PMID 24567903, Free PMC Article
    4. Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster. Sonn JY, et al. Proc Natl Acad Sci U S A, 2018 Jul 3. PMID 29915051, Free PMC Article
    5. Germline-dependent gene expression in distant non-gonadal somatic tissues of Drosophila. Parisi MJ, et al. BMC Genomics, 2010 Jun 1. PMID 20515475, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables D-amino-acid oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-amino-acid oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-amino-acid oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-amino acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in D-amino acid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in D-amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D-amino acid oxidase 2
    Names
    CG11236-PA
    CG11236-PB
    D-amino acid oxidase
    Daao2-PA
    Daao2-PB
    NP_001245914.1
    NP_609075.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6803011..6804372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135231.3 → NP_609075.1  D-amino acid oxidase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609075.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM80
      Related
      FBpp0078967
      Conserved Domains (1) summary
      pfam01266
      Location:4 → 325
      DAO; FAD dependent oxidoreductase

    2. NM_001258985.2 → NP_001245914.1  D-amino acid oxidase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245914.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDG8
      Conserved Domains (1) summary
      pfam01266
      Location:4 → 322
      DAO; FAD dependent oxidoreductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDG8 M9NDG8
    Q9VM80 Q9VM80

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