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    l(2)41Ab lethal (2) 41Ab [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740691, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(2)41Abprovided by FlyBase
    Official Full Name
    lethal (2) 41Abprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262123
    Locus tag
    Dmel_CG41265
    See related
    AllianceGenome:FB:FBgn0262123
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1(2R)B; 41Ab; CG40214; CG40334; CG41265; Dmel\CG41265; GroupI; l(2)EMS45-10; l(2R)B
    Summary
    Predicted to be involved in axonemal dynein complex assembly and cilium movement. Predicted to be active in cytoplasm. Is expressed in chordotonal neurons and spermatogonium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 15. Orthologous to human CCDC40 (coiled-coil domain 40 molecular ruler complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(2)41Ab in Genome Data Viewer
    Location:
    41A1-41A1; 2-55 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (1349392..1443935)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2RHet NW_001848856.1 (476025..570568)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44042 Neighboring gene long non-coding RNA:CR44043 Neighboring gene yeti Neighboring gene Maf1 Neighboring gene Branched chain keto acid dehydrogenase E1 subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of heterochromatin in the expression of a heterochromatic gene, the rolled locus of Drosophila melanogaster. Eberl DF, et al. Genetics, 1993 May. PMID 8514136, Free PMC Article
    2. B.2.16 is a non-lethal modifier of the Dark(82) mosaic eye phenotype in Drosophila melanogaster. Vrailas-Mortimer AD, et al. MicroPubl Biol, 2021 Jan 18. PMID 33474526, Free PMC Article
    3. Genetic analysis of the centromeric heterochromatin of chromosome 2 of Drosophila melanogaster: deficiency mapping of EMS-induced lethal complementation groups. Hilliker AJ. Genetics, 1976 Aug. PMID 823073, Free PMC Article
    4. 1(2)41Aa, a heterochromatic gene of Drosophila melanogaster, is required for mitotic and meiotic chromosome condensation. Cenci G, et al. Genet Res, 2003 Feb. PMID 12693679
    5. Cytogenetic analysis of the second chromosome heterochromatin of Drosophila melanogaster. Dimitri P. Genetics, 1991 Mar. PMID 1707844, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 1374261-1374683 mobile_element_type = transposon:invader1{}6536
    • Loc: 1396478-1397528 mobile_element_type = transposon:1360{}6326
    • Loc: 1423542-1424649 mobile_element_type = transposon:1360{}6328

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in axoneme assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium movement ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lethal (2) 41Ab
    Names
    CG41265-PA
    CG41265-PB
    l(2)41Ab-PA
    l(2)41Ab-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      1349392..1443935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001110887.2 → NP_001104357.1  lethal (2) 41Ab, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104357.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B7P7M6
      Conserved Domains (1) summary
      COG1196
      Location:53 → 808
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_001110886.2 → NP_001104356.1  lethal (2) 41Ab, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104356.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHM9
      Conserved Domains (1) summary
      COG1196
      Location:1 → 725
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B7P7M6 A0A0B7P7M6
    A0A0C4DHM9 A0A0C4DHM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials