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    E(Pc) Enhancer of Polycomb [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36238, updated on 9-Dec-2024

    Summary

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    Official Symbol
    E(Pc)provided by FlyBase
    Official Full Name
    Enhancer of Polycombprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000581
    Locus tag
    Dmel_CG7776
    See related
    AllianceGenome:FB:FBgn0000581
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-48Ac; CG7776; Dmel\CG7776; e(pc); e(Pc); E(pc); E(PC); EN2-2; GH05739; GH14582; III; l(2)28-28-12
    Summary
    Involved in chromatin organization and dendrite guidance. Located in nucleus and polytene chromosome. Part of NuA4 histone acetyltransferase complex. Is expressed in optic lobe neuroepithelial cell; organism; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including EPC1 (enhancer of polycomb homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See E(Pc) in Genome Data Viewer
    Location:
    47F13-47F15; 2-64 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11452043..11465270)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7339548..7352775)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene prip Neighboring gene quiver Neighboring gene invected Neighboring gene engrailed

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Critical genomic regulation mediated by Enhancer of Polycomb. Searle NE, et al. Curr Genet, 2018 Feb. PMID 28884217, Free PMC Article
    2. Homoeosis in Drosophila: anterior and posterior transformations of Polycomb lethal embryos. Sato T, et al. Dev Biol, 1985 Jul. PMID 4007267
    3. Enhancer of polycomb maintains germline activity and genome integrity in Drosophila testis. Feng L, et al. Cell Death Differ, 2018 Aug. PMID 29362481, Free PMC Article
    4. Homoeosis in Drosophila: a new enhancer of polycomb and related homoeotic mutations. Sato T, et al. Genetics, 1983 Oct. PMID 17246164, Free PMC Article
    5. The chromatin remodeling factor Bap55 functions through the TIP60 complex to regulate olfactory projection neuron dendrite targeting. Tea JS, et al. Neural Dev, 2011 Feb 1. PMID 21284845, Free PMC Article

    See all (128) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. esc and E(Pc) mutants enhance homologous recombination by modulating the histone acetylation status of histone H4 at the double-strand break
      Title: Mutations in the extra sex combs and Enhancer of Polycomb genes increase homologous recombination in somatic cells of Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NuA4 histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of histone acetyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of piccolo histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    enhancer of polycomb
    Names
    CG7776-PA
    CG7776-PB
    CG7776-PC
    CG7776-PD
    CG7776-PE
    E(Pc)-PA
    E(Pc)-PB
    E(Pc)-PC
    E(Pc)-PD
    E(Pc)-PE
    enhancer of NA9 2-2
    transcript group III

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11452043..11465270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273968.1 → NP_001260897.1  enhancer of polycomb, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260897.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFP2, O96542
      Conserved Domains (1) summary
      pfam10513
      Location:7 → 139
      EPL1; Enhancer of polycomb-like

    2. NM_001273967.1 → NP_001260896.1  enhancer of polycomb, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260896.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KET9, O96542
      Conserved Domains (1) summary
      pfam10513
      Location:7 → 139
      EPL1; Enhancer of polycomb-like

    3. NM_078974.3 → NP_523698.2  enhancer of polycomb, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523698.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96542, Q0E9C2
      Related
      FBpp0087238
      Conserved Domains (1) summary
      pfam10513
      Location:7 → 139
      EPL1; Enhancer of polycomb-like

    4. NM_001273966.2 → NP_001260895.1  enhancer of polycomb, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260895.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEK1, O96542
      Conserved Domains (1) summary
      pfam10513
      Location:7 → 139
      EPL1; Enhancer of polycomb-like

    5. NM_165836.3 → NP_725054.1  enhancer of polycomb, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725054.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96542, Q0E9C2
      Related
      FBpp0087239
      Conserved Domains (1) summary
      pfam10513
      Location:7 → 139
      EPL1; Enhancer of polycomb-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEK1 A0A0B4KEK1
    A0A0B4KET9 A0A0B4KET9
    A0A0B4KFP2 A0A0B4KFP2
    O96542 O96542
    Q0E9C2 Q0E9C2
    Q8MRN0 Q8MRN0
    Q95TF0 Q95TF0

    Gene LinkOut

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