5-HT2B 5-hydroxytryptamine (serotonin) receptor 2B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: 5-HT2Bprovided by FlyBase
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 2Bprovided by FlyBase
Primary source: FLYBASE:FBgn0261929
Locus tag: Dmel_CG42796
See related: AllianceGenome:FB:FBgn0261929
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5-HT-2b; 5-HT[[2B]]; 5HT1b; 5HT2b; 5HT2B; anon-WO0170980.94; anon-WO0170980.95; anon-WO0170980.97; anon-WO0170980.98; CG42796; CG7994; CG8007; d5-HT2B; Dm5-ht2b; Dm5-HT2B; Dm5-HT[[2B]]; Dmel\CG42796
Old locus tag: Dmel_CG7994; Dmel_CG8007
Summary: Enables G protein-coupled serotonin receptor activity. Involved in serotonin receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in adult head and hemocyte. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcoholic psychosis; cocaine dependence; nicotine dependence; and steatotic liver disease (multiple). Orthologous to several human genes including HTR2A (5-hydroxytryptamine receptor 2A) and HTR2C (5-hydroxytryptamine receptor 2C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 85A3-85A5; 3-48 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (8578205..8629996)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (4403927..4455718)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serotonergic modulation of visual neurons in Drosophila melanogaster.
Title: Serotonergic modulation of visual neurons in Drosophila melanogaster.
5HT2b expression in a small subset of, probably a single pair of, neurons in the dorsal fan-shaped body (dFB) is functionally essential: elimination of the 5HT2b gene from these neurons led to loss of sleep homeostasis.
Title: Sleep homeostasis regulated by 5HT2b receptor in a small subset of neurons in the dorsal fan-shaped body of drosophila.
5-HT2b receptor is involved in the action of 5-HT on the heart rate in the larval stage.
Title: Pharmacological and genetic identification of serotonin receptor subtypes on Drosophila larval heart and aorta.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled amine receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in serotonin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: 5-hydroxytryptamine (serotonin) receptor 2B

Names: 5-HT2B-PD; 5-HT2B-PE; 5-HT2B-PF; CG42796-PD; CG42796-PE; CG42796-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

8578205..8629996

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300309.1 → NP_001287238.1 5-hydroxytryptamine (serotonin) receptor 2B, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287238.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8INQ6, S4Z9K9

Conserved Domains (2) summary

pfam00001
Location:90 → 262

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:90 → 238

7tm_4; Olfactory receptor
NM_001275444.2 → NP_001262373.1 5-hydroxytryptamine (serotonin) receptor 2B, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262373.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KFU6

Conserved Domains (2) summary

pfam00001
Location:90 → 262

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:90 → 238

7tm_4; Olfactory receptor
NM_141549.4 → NP_649806.2 5-hydroxytryptamine (serotonin) receptor 2B, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649806.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8INQ6, S4Z9K9

Conserved Domains (2) summary

pfam00001
Location:90 → 262

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:90 → 238

7tm_4; Olfactory receptor