U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tdrd3 Tudor domain containing 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39612, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tdrd3provided by FlyBase
    Official Full Name
    Tudor domain containing 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0036450
    Locus tag
    Dmel_CG13472
    See related
    AllianceGenome:FB:FBgn0036450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13472; Dmel\CG13472; dTDRD3; Tdrd; TDRD; TDRD3
    Summary
    Enables protein-macromolecule adaptor activity; single-stranded DNA binding activity; and single-stranded RNA binding activity. Involved in DNA topological change and siRNA-mediated heterochromatin formation. Part of DNA topoisomerase III-beta-TDRD3 complex. Is expressed in adult head; embryonic brain; and organism. Orthologous to human TDRD3 (tudor domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tdrd3 in Genome Data Viewer
    Location:
    70F5-70F6; 3-42 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14786791..14789665)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14779891..14782765)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene myopic Neighboring gene brummer Neighboring gene Helicase with zinc finger Neighboring gene NHP2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Deciphering discord: How Drosophila research has enhanced our understanding of the importance of FMRP in different spatial and temporal contexts. Weisz ED, et al. Exp Neurol, 2015 Dec. PMID 26026973
    2. DNA and RNA topoisomerase activities of Top3β are promoted by mediator protein Tudor domain-containing protein 3. Siaw GE, et al. Proc Natl Acad Sci U S A, 2016 Sep 20. PMID 27582462, Free PMC Article
    3. RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals. Ahmad M, et al. Nucleic Acids Res, 2016 Jul 27. PMID 27257063, Free PMC Article
    4. piRNAs as Modulators of Disease Pathogenesis. Rayford KJ, et al. Int J Mol Sci, 2021 Feb 27. PMID 33673453, Free PMC Article
    5. Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation. Xu D, et al. Nat Neurosci, 2013 Sep. PMID 23912945, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA topological change IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siRNA-mediated heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA topoisomerase III-beta-TDRD3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DNA topoisomerase III-beta-TDRD3 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tudor domain containing 3
    Names
    CG13472-PA
    Tdrd3-PA
    tudor domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14786791..14789665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140467.3 → NP_648724.1  tudor domain containing 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648724.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUH8
      Related
      FBpp0075441
      Conserved Domains (3) summary
      cd04508
      Location:735 → 781
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd14297
      Location:246 → 284
      UBA2_spUBP14_like; UBA2 domain found in Schizosaccharomyces pombe ubiquitin carboxyl-terminal hydrolase 14 (spUBP14) and similar proteins
      pfam08585
      Location:39 → 157
      RMI1_N; RecQ mediated genome instability protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUH8 Q9VUH8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools