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    Sgs3 Salivary gland secretion 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39288, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sgs3provided by FlyBase
    Official Full Name
    Salivary gland secretion 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0003373
    Locus tag
    Dmel_CG11720
    See related
    AllianceGenome:FB:FBgn0003373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    68C GII; CG11720; Dmel\CG11720; DMSGS378; Glue; Muc68Cb; Sgs; sgs-3; Sgs-3; SGS-3; sgs3; SGS378
    Summary
    Predicted to be an extracellular matrix structural constituent. Involved in puparial adhesion. Located in adhesive extracellular matrix. Is expressed in several structures, including adult heart; embryonic/larval Malpighian tubule; embryonic/larval fat body; embryonic/larval proventriculus; and salivary gland. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Sgs3 in Genome Data Viewer
    Location:
    68C11-68C11; 3-36 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11512221..11513402)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11505321..11506502)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Salivary gland secretion 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene alpha-L-fucosidase Neighboring gene Mob2 Neighboring gene mir-4968 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gross morphology and adhesion-associated physical properties of Drosophila larval salivary gland glue secretion. Beňo M, et al. Sci Rep, 2024 Apr 29. PMID 38684688, Free PMC Article
    2. Starvation selection reduces and delays larval ecdysone production and signaling. Clark JM, et al. J Exp Biol, 2023 Sep 15. PMID 37671530, Free PMC Article
    3. Drosophila glue gene Sgs-3: sequences required for puffing and transcriptional regulation. Crosby MA, et al. Dev Biol, 1986 Dec. PMID 2431935
    4. Evolution and expression of the Sgs-3 glue gene of Drosophila. Martin CH, et al. J Mol Biol, 1988 May 20. PMID 3138416
    5. Drosophila Sgs3 TATA: effects of point mutations on expression in vivo and protein binding in vitro with staged nuclear extracts. Giangrande A, et al. EMBO J, 1989 Nov. PMID 2583107, Free PMC Article

    See all (165) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. stage-precocious activation of Sgs3 required expression of the Broad-complex, similar to normal Sgs3 developmental regulation, and a small level of nutritional input.
      Title: Glue protein production can be triggered by steroid hormone signaling independent of the developmental program in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in puparial adhesion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adhesive extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    salivary gland secretion 3
    Names
    CG11720-PA
    Sgs3-PA
    gene IV
    group IV
    mucin 68Cb
    salivary gland glue protein 3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11512221..11513402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079300.3 → NP_524024.1  salivary gland secretion 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524024.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P02840, Q9VTJ2
      Related
      FBpp0075827
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02840.1 P02840

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