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    CG10654 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39428, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10654provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036294
    Locus tag
    Dmel_CG10654
    See related
    AllianceGenome:FB:FBgn0036294
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10654
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic hindgut; embryonic proventriculus inner layer; larval muscle system; and larval somatic muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10654 in Genome Data Viewer
    Location:
    69C4-69C4; 3-38 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12505374..12507840, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12498474..12500940, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43868 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene vihar Neighboring gene sticky Neighboring gene long non-coding RNA:CR45168 Neighboring gene trailer hitch

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation. Máthé E, et al. Curr Biol, 2004 Oct 5. PMID 15458643
    2. Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac. D'Avino PP, et al. J Cell Biol, 2004 Jul 5. PMID 15240570, Free PMC Article
    3. Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes. Stevaux O, et al. Cell Cycle, 2005 Sep. PMID 16082225
    4. Structural basis of diversity and homodimerization specificity of zinc-finger-associated domains in Drosophila. Bonchuk A, et al. Nucleic Acids Res, 2021 Feb 26. PMID 33638995, Free PMC Article
    5. Predicting spatial and temporal gene expression using an integrative model of transcription factor occupancy and chromatin state. Wilczynski B, et al. PLoS Comput Biol, 2012. PMID 23236268, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10654-PA
    CG10654-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12505374..12507840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274838.1 → NP_001261767.1  uncharacterized protein Dmel_CG10654, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261767.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFA9, Q4V5B2
      Conserved Domains (3) summary
      sd00017
      Location:289 → 314
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:323 → 345
      zf-C2H2; Zinc finger, C2H2 type
      pfam07776
      Location:39 → 115
      zf-AD; Zinc-finger associated domain (zf-AD)

    2. NM_140326.2 → NP_648583.2  uncharacterized protein Dmel_CG10654, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648583.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5B2, Q9VTY7
      Related
      FBpp0075703
      Conserved Domains (3) summary
      sd00017
      Location:263 → 288
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:297 → 319
      zf-C2H2; Zinc finger, C2H2 type
      pfam07776
      Location:39 → 115
      zf-AD; Zinc-finger associated domain (zf-AD)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFA9 M9PFA9
    Q8MTU5 Q8MTU5
    Q9VTY7 Q9VTY7

    Gene LinkOut

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