sNPF-R short neuropeptide F receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sNPF-Rprovided by FlyBase
Official Full Name: short neuropeptide F receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0036934
Locus tag: Dmel_CG7395
See related: AllianceGenome:FB:FBgn0036934
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0131005.1; CG18639; CG7395; CG7395/CG18639; CT22771; Dmel\CG7395; Drm-NPFR76F; Drm-sNPF-R; GPCR60; NPFR76F; sNPF R; snpfr; sNPFR; sNPFR1
Summary: Enables short neuropeptide F receptor activity. Involved in several processes, including neuropeptide signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of feeding behavior. Located in plasma membrane. Is expressed in several structures, including ganglia; gut section; insulin secreting cell of pars intercerebralis; larval midline neurons; and sensory cluster. Human ortholog(s) of this gene implicated in Huntington's disease; hypertension; morbid obesity; and obesity. Orthologous to several human genes including PRLHR (prolactin releasing hormone receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20058511..20089007, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20051611..20082107, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables neuropeptide Y receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide receptor activity	ISM Inferred from Sequence Model more info	PubMed
enables short neuropeptide F receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISM Inferred from Sequence Model more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

Names: CG7395-PA; CG7395-PB; neuropeptide F-like receptor 76F; neuropeptide-Y-receptor; sNPF receptor; sNPF-R-PA; sNPF-R-PB

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