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    Kpc2 Kip1 ubiquitination-promoting complex subunit 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37261, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kpc2provided by FlyBase
    Official Full Name
    Kip1 ubiquitination-promoting complex subunit 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0028372
    Locus tag
    Dmel_CG11025
    See related
    AllianceGenome:FB:FBgn0028372
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11025; dKPC2; Dmel\CG11025; isopeptidase-T-3; Isopeptidase-T-3; IsoT-3; ISOT-3; ISOT-3A
    Summary
    Located in endoplasmic reticulum and sperm flagellum. Part of ubiquitin ligase complex. Is expressed in wing hinge primordium and wing pouch. Orthologous to human UBAC1 (UBA domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Kpc2 in Genome Data Viewer
    Location:
    56E1-56E1; 2-90 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19670618..19673477)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15558123..15560982)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hiiragi Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic screen in Drosophila reveals an unexpected role for the KIP1 ubiquitination-promoting complex in male fertility. Li W, et al. PLoS Genet, 2020 Dec. PMID 33378371, Free PMC Article
    2. Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration. Jantrapirom S, et al. Int J Mol Sci, 2019 Apr 17. PMID 30999567, Free PMC Article
    3. Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling. Zhou Z, et al. Dev Cell, 2015 Jul 6. PMID 26120032, Free PMC Article
    4. Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model. Park JE, et al. Exp Mol Med, 2023 Jul. PMID 37464094, Free PMC Article
    5. Genetic annotation of gain-of-function screens using RNA interference and in situ hybridization of candidate genes in the Drosophila wing. Molnar C, et al. Genetics, 2012 Oct. PMID 22798488, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Kip1 ubiquitination-promoting complex subunit 2
    Names
    CG11025-PA
    CG11025-PB
    CG11025-PC
    Kpc2-PA
    Kpc2-PB
    Kpc2-PC
    isopeptidase T-3
    isopeptidase-T-3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19670618..19673477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274169.2 → NP_001261098.1  Kip1 ubiquitination-promoting complex subunit 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261098.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFW5
      Conserved Domains (2) summary
      cd14304
      Location:434 → 472
      UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
      cl21463
      Location:345 → 384
      UBA_like_SF; UBA domain-like superfamily

    2. NM_137595.2 → NP_611439.2  Kip1 ubiquitination-promoting complex subunit 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611439.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86LF0
      Related
      FBpp0085669
      Conserved Domains (2) summary
      cd14304
      Location:430 → 468
      UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
      cl21463
      Location:341 → 380
      UBA_like_SF; UBA domain-like superfamily

    3. NM_166373.4 → NP_725921.1  Kip1 ubiquitination-promoting complex subunit 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725921.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBP3, Q8IHD7
      Related
      FBpp0085670
      Conserved Domains (2) summary
      cd14304
      Location:308 → 346
      UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
      cl21463
      Location:219 → 258
      UBA_like_SF; UBA domain-like superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFW5 A0A0B4KFW5
    A1ZBP3 A1ZBP3
    Q86LF0 Q86LF0
    Q8IHD7 Q8IHD7
    Q9U904 Q9U904

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