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    Mal-B2 Maltase B2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34598, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mal-B2provided by FlyBase
    Official Full Name
    Maltase B2provided by FlyBase
    Primary source
    FLYBASE:FBgn0032382
    Locus tag
    Dmel_CG14935
    See related
    AllianceGenome:FB:FBgn0032382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14935; Dmel\CG14935; Drome_B2; FBgn0032382; mal_B2
    Summary
    Enables alpha-1,4-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mal-B2 in Genome Data Viewer
    Location:
    33A4-33A4; 2-45 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11849958..11852881)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11849958..11852881)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phosphodiesterase 1c Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Maltase B1 Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 33a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AGI, a previously unreported D. melanogaster alpha-glucosidase: partial purification, characterization, and cytogenetic mapping. Parker GF, et al. Biochem Genet, 1996 Apr. PMID 8734412
    2. Association between duplicated maltase genes and the transcriptional regulation for the carbohydrate changes in Drosophila melanogaster. Inomata N, et al. Gene, 2019 Feb 20. PMID 30399425
    3. Assessment of genome-wide protein function classification for Drosophila melanogaster. Mi H, et al. Genome Res, 2003 Sep. PMID 12952880, Free PMC Article
    4. A Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome. Ren J, et al. Hum Mol Genet, 2011 Sep 1. PMID 21653638, Free PMC Article
    5. The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila. Sieber MH, et al. Cell Metab, 2009 Dec. PMID 19945405, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-1,4-glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-1,4-glucosidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    maltase B2
    Names
    CG14935-PA
    CG14935-PE
    CG14935-PF
    Mal-B2-PA
    Mal-B2-PE
    Mal-B2-PF
    NP_001188791.2
    NP_609523.2
    NP_723693.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11849958..11852881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135679.5 → NP_609523.2  maltase B2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609523.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPA2, Q8SYS2, Q9VKE5
      Related
      FBpp0079860
      Conserved Domains (3) summary
      cd11328
      Location:14 → 483
      AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
      TIGR02403
      Location:15 → 521
      trehalose_treC; alpha,alpha-phosphotrehalase
      cl02706
      Location:491 → 524
      Malt_amylase_C; Maltogenic Amylase, C-terminal domain

    2. NM_001201862.1 → NP_001188791.2  maltase B2, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4P1SA55, A9UND4
      Conserved Domains (2) summary
      cd11328
      Location:33 → 502
      AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
      cl02706
      Location:510 → 541
      Malt_amylase_C; Maltogenic Amylase, C-terminal domain

    3. NM_164975.3 → NP_723693.3  maltase B2, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4P1SA55, A9UND4
      Conserved Domains (2) summary
      cd11328
      Location:33 → 502
      AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
      cl02706
      Location:510 → 541
      Malt_amylase_C; Maltogenic Amylase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4P1SA55 A0A4P1SA55
    Q8IPA2 Q8IPA2
    Q8SYS2 Q8SYS2

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