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    l(3)72Dr lethal (3) 72Dr [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39778, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(3)72Drprovided by FlyBase
    Official Full Name
    lethal (3) 72Drprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263608
    Locus tag
    Dmel_CG32154
    See related
    AllianceGenome:FB:FBgn0263608
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32154; CG5082; Dmel\CG32154
    Summary
    Predicted to enable gamma-glutamyl-peptidase activity. Predicted to be involved in tetrahydrofolylpolyglutamate metabolic process. Predicted to be active in vacuole. Orthologous to human GGH (gamma-glutamyl hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(3)72Dr in Genome Data Viewer
    Location:
    72D10-72D10; 3-44 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16237723..16239462)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16230823..16232562)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Mediator complex subunit 10 Neighboring gene lethal (3) 72Dp Neighboring gene Heat shock protein cognate 20 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans. Kislukhin G, et al. G3 (Bethesda), 2013 Aug 7. PMID 23733889, Free PMC Article
    2. Molecular genetic analyses of polytene chromosome region 72A-D in Drosophila melanogaster reveal a gene desert in 72D. Cooper MT, et al. PLoS One, 2011. PMID 21853143, Free PMC Article
    3. Survival Rate and Transcriptional Response upon Infection with the Generalist Parasite Beauveria bassiana in a World-Wide Sample of Drosophila melanogaster. Paparazzo F, et al. PLoS One, 2015. PMID 26154519, Free PMC Article
    4. Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors. Tegeder I, et al. J Neurooncol, 2019 Jan. PMID 30446899
    5. A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins. Guichard A, et al. Cell Rep, 2023 Aug 29. PMID 37480566, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables gamma-glutamyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables omega peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tetrahydrofolylpolyglutamate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lethal (3) 72Dr
    Names
    CG32154-PA
    l(3)72Dr-PA
    NP_730120.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16237723..16239462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168656.2 → NP_730120.1  lethal (3) 72Dr [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730120.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV00
      Related
      FBpp0075215
      Conserved Domains (1) summary
      cd01747
      Location:23 → 313
      GATase1_Glutamyl_Hydrolase; Type 1 glutamine amidotransferase (GATase1) domain found in gamma-Glutamyl Hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VV00 Q9VV00

    Gene LinkOut

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