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    mTerf3 mitochondrial transcription termination factor 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40279, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mTerf3provided by FlyBase
    Official Full Name
    mitochondrial transcription termination factor 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0037008
    Locus tag
    Dmel_CG5047
    See related
    AllianceGenome:FB:FBgn0037008
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5047; D-MTERF3; Dmel\CG5047; DmMterf3; DmMTERF3; Mterf3; MTERF3
    Summary
    Enables large ribosomal subunit rRNA binding activity. Involved in mitochondrial large ribosomal subunit assembly; positive regulation of mitochondrial translation; and regulation of mitochondrial transcription. Located in mitochondrial matrix. Is expressed in organism. Orthologous to human MTERF3 (mitochondrial transcription termination factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mTerf3 in Genome Data Viewer
    Location:
    77C6-77C6; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20519590..20520772, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20512690..20513872, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene BNIP3 Neighboring gene uncharacterized protein Neighboring gene Phosphatidylserine synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitotype Interacts With Diet to Influence Longevity, Fitness, and Mitochondrial Functions in Adult Female Drosophila. Towarnicki SG, et al. Front Genet, 2018. PMID 30555517, Free PMC Article
    2. MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals. Wredenberg A, et al. PLoS Genet, 2013. PMID 23300484, Free PMC Article
    3. The complex role of transcription factor GAGA in germline death during Drosophila spermatogenesis: transcriptomic and bioinformatic analyses. Fedorova S, et al. PeerJ, 2023. PMID 36643636, Free PMC Article
    4. MTERF3, the most conserved member of the mTERF-family, is a modular factor involved in mitochondrial protein synthesis. Roberti M, et al. Biochim Biophys Acta, 2006 Sep-Oct. PMID 16787637
    5. D-MTERF5 is a novel factor modulating transcription in Drosophila mitochondria. Bruni F, et al. Mitochondrion, 2012 Sep. PMID 22784680, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We demonstrate here that decreased expression of MTERF3 not only leads to activation of mtDNA transcription, but also impairs assembly of the large mitochondrial ribosomal subunit.
      Title: MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals.
    2. These results indicate that D-MTERF3 is involved in mitochondrial translation.
      Title: MTERF3, the most conserved member of the mTERF-family, is a modular factor involved in mitochondrial protein synthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables large ribosomal subunit rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial large ribosomal subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial ribosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in mitochondrial transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitochondrial transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial transcription termination factor 3
    Names
    CG5047-PA
    mTerf3-PA
    mitochondrial transcription termination factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20519590..20520772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140983.3 → NP_649240.1  mitochondrial transcription termination factor 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649240.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q06YR8, Q9VPD5
      Related
      FBpp0077873
      Conserved Domains (1) summary
      cl19765
      Location:122 → 307
      mTERF; mTERF
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPD5.1 Q9VPD5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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