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    prt portabella [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 117368, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prtprovided by FlyBase
    Official Full Name
    portabellaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0043005
    Locus tag
    Dmel_CG10251
    See related
    AllianceGenome:FB:FBgn0043005
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10251; Dmel\CG10251
    Summary
    Predicted to enable serotonin:sodium:chloride symporter activity. Involved in male mating behavior and olfactory learning. Located in synaptic vesicle. Is expressed in several structures, including adult head; adult protocerebrum; ganglia; synaptic neuropil domain; and synaptic neuropil subdomain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See prt in Genome Data Viewer
    Location:
    95A7-95A8; 3-80 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23696372..23699027, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19522094..19524749, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43903 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glucocerebrosidase 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A putative vesicular transporter expressed in Drosophila mushroom bodies that mediates sexual behavior may define a neurotransmitter system. Brooks ES, et al. Neuron, 2011 Oct 20. PMID 22017990, Free PMC Article
    2. Vesicular neurotransmitter transporters in Drosophila melanogaster. Deshpande SA, et al. Biochim Biophys Acta Biomembr, 2020 Dec 1. PMID 32305263, Free PMC Article
    3. Circadian Structural Plasticity Drives Remodeling of E Cell Output. Duhart JM, et al. Curr Biol, 2020 Dec 21. PMID 33065014
    4. A Syndromic Neurodevelopmental Disorder Caused by Mutations in SMARCD1, a Core SWI/SNF Subunit Needed for Context-Dependent Neuronal Gene Regulation in Flies. Nixon KCJ, et al. Am J Hum Genet, 2019 Apr 4. PMID 30879640, Free PMC Article
    5. Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits. Godfrey RK, et al. Acta Neuropathol Commun, 2023 Oct 20. PMID 37864255, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serotonin:sodium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminergic neurotransmitter loading into synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    portabella
    Names
    CG10251-PB
    prt-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23696372..23699027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104417.2 → NP_001097887.1  portabella [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097887.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4VCK6, Q9VCJ5
      Conserved Domains (2) summary
      cd06174
      Location:212 → 565
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:212 → 532
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCJ5 Q9VCJ5

    Gene LinkOut

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