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    Rab26 Rab26 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40359, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rab26provided by FlyBase
    Official Full Name
    Rab26provided by FlyBase
    Primary source
    FLYBASE:FBgn0086913
    Locus tag
    Dmel_CG34410
    See related
    AllianceGenome:FB:FBgn0086913
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF51708; CG32439; CG34410; CG7605; Dmel\CG34410; DmRab26; Q8IPT6; Q9VP48; rab26
    Old locus tag
    CG32439; CG7605; Dmel_CG32439; Dmel_CG7605
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Involved in symbiont entry into host cell. Located in recycling endosome and synapse. Is expressed in several structures, including Bolwig organ; adult head; brain; mushroom body; and synaptic neuropil domain. Orthologous to several human genes including RAB37 (RAB37, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Rab26 in Genome Data Viewer
    Location:
    78C7-78C7; 3-47 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21318774..21335027)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21311874..21328127)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Polycomb Neighboring gene long non-coding RNA:CR45674 Neighboring gene antisense RNA:CR46068 Neighboring gene TBC1 domain family member 8/9 Neighboring gene Tsr1 ribosome assembly factor Neighboring gene uncharacterized protein Neighboring gene earthbound 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The GTPase Rab26 links synaptic vesicles to the autophagy pathway. Binotti B, et al. Elife, 2015 Feb 2. PMID 25643395, Free PMC Article
    2. Rab26 controls secretory granule maturation and breakdown in Drosophila. Boda A, et al. Cell Mol Life Sci, 2023 Jan 4. PMID 36600084, Free PMC Article
    3. Local endocytosis triggers dendritic thinning and pruning in Drosophila sensory neurons. Kanamori T, et al. Nat Commun, 2015 Mar 12. PMID 25761586
    4. Commissureless regulation of axon outgrowth across the midline is independent of Rab function. van den Brink DM, et al. PLoS One, 2013. PMID 23696892, Free PMC Article
    5. Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo. White JA 2nd, et al. Hum Mol Genet, 2015 Dec 20. PMID 26450517, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rab26 controls secretory granule maturation and breakdown in Drosophila.
      Title: Rab26 controls secretory granule maturation and breakdown in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in symbiont entry into host cell HMP PubMed 
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in recycling endosome HDA PubMed 
    located_in synapse HDA PubMed 
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Rab26
    Names
    CG34410-PB
    CG34410-PC
    CG34410-PD
    CG34410-PE
    CG34410-PF
    CG34410-PG
    Rab26-PB
    Rab26-PC
    Rab26-PD
    Rab26-PE
    Rab26-PF
    Rab26-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21318774..21335027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300213.1 → NP_001287142.1  Rab26, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287142.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95R32, Q9VP48
      UniProtKB/TrEMBL
      B5RJ70
      Conserved Domains (2) summary
      smart00175
      Location:192 → 356
      RAB; Rab subfamily of small GTPases
      cd04112
      Location:191 → 385
      Rab26; Rab GTPase family 26 (Rab26)

    2. NM_001275222.1 → NP_001262151.1  Rab26, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262151.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V496, Q4V4D6, Q8IPT6
      Conserved Domains (2) summary
      smart00175
      Location:214 → 378
      RAB; Rab subfamily of small GTPases
      cd04112
      Location:214 → 407
      Rab26; Rab GTPase family 26 (Rab26)

    3. NM_141046.4 → NP_649303.2  Rab26, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649303.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95R32, Q9VP48
      UniProtKB/TrEMBL
      B5RJ70
      Related
      FBpp0111589
      Conserved Domains (2) summary
      smart00175
      Location:192 → 356
      RAB; Rab subfamily of small GTPases
      cd04112
      Location:191 → 385
      Rab26; Rab GTPase family 26 (Rab26)

    4. NM_001104188.3 → NP_001097658.1  Rab26, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097658.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V496, Q4V4D6, Q8IPT6
      Conserved Domains (2) summary
      smart00175
      Location:214 → 378
      RAB; Rab subfamily of small GTPases
      cd04112
      Location:214 → 407
      Rab26; Rab GTPase family 26 (Rab26)

    5. NM_001170017.1 → NP_001163488.1  Rab26, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163488.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V496, Q4V4D6, Q8IPT6
      Conserved Domains (2) summary
      smart00175
      Location:214 → 378
      RAB; Rab subfamily of small GTPases
      cd04112
      Location:214 → 407
      Rab26; Rab GTPase family 26 (Rab26)

    6. NM_001275223.1 → NP_001262152.1  Rab26, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262152.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PG39, Q4V4D6
      Conserved Domains (1) summary
      cl21455
      Location:211 → 370
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5RJ70 B5RJ70
    M9PG39 M9PG39
    Q8IPT6 Q8IPT6
    Q9VP48.2 Q9VP48

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