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    Socs16D Suppressor of Cytokine Signaling at 16D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32760, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Socs16Dprovided by FlyBase
    Official Full Name
    Suppressor of Cytokine Signaling at 16Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030869
    Locus tag
    Dmel_CG8146
    See related
    AllianceGenome:FB:FBgn0030869
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8146; Dmel\CG8146; dmSocs16D; SOCS; Socs 16D; socs16D; SOCS16D; Socs16E
    Summary
    Enables myosin binding activity. Involved in positive regulation of TORC1 signaling and vascular endothelial growth factor receptor signaling pathway. Is expressed in follicle cell. Orthologous to human SOCS7 (suppressor of cytokine signaling 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Socs16D in Genome Data Viewer
    Location:
    16D4-16D4; 1-58 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17820764..17827564, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17714797..17721597, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ods-site homeobox Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44691 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Socs36E attenuates STAT signaling to optimize motile cell specification in the Drosophila ovary. Monahan AJ, et al. Dev Biol, 2013 Jul 15. PMID 23583584, Free PMC Article
    2. Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities. Rawlings JS, et al. BMC Cell Biol, 2004 Oct 15. PMID 15488148, Free PMC Article
    3. Cotranscriptional recruitment of the dosage compensation complex to X-linked target genes. Kind J, et al. Genes Dev, 2007 Aug 15. PMID 17699750, Free PMC Article
    4. The fertile field of Drosophila Jak/STAT signalling. Hombría JC, et al. Curr Biol, 2002 Aug 20. PMID 12194841
    5. Drosophila SOCS Proteins. Stec WJ, et al. J Signal Transduct, 2011. PMID 22203896, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    suppressor of cytokine signaling at 16D
    Names
    CG8146-PA
    CG8146-PB
    Socs16D-PA
    Socs16D-PB
    suppressor of cytokine signaling at 16E

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17820764..17827564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272733.2 → NP_001259662.1  suppressor of cytokine signaling at 16D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259662.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHY7
      Conserved Domains (2) summary
      cd10388
      Location:839 → 937
      SH2_SOCS7; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03741
      Location:960 → 1009
      SOCS_SOCS7; SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal ...

    2. NM_078666.4 → NP_523390.3  suppressor of cytokine signaling at 16D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523390.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX18
      Conserved Domains (2) summary
      cd10388
      Location:834 → 932
      SH2_SOCS7; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03741
      Location:955 → 1004
      SOCS_SOCS7; SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHY7 M9PHY7
    Q9VX18 Q9VX18

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