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    Prosbeta3 Proteasome beta3 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41079, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prosbeta3provided by FlyBase
    Official Full Name
    Proteasome beta3 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026380
    Locus tag
    Dmel_CG11981
    See related
    AllianceGenome:FB:FBgn0026380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    11981; beta-3; Beta-3; beta3; CG11981; Dmel\CG11981; Pros beta3
    Summary
    Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; germline cell; and mesoderm. Orthologous to human PSMB3 (proteasome 20S subunit beta 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prosbeta3 in Genome Data Viewer
    Location:
    85C2-85C2; 3-48 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9005313..9006226, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4831035..4831948, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Iruka Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteasome Structure and Assembly. Budenholzer L, et al. J Mol Biol, 2017 Nov 10. PMID 28583440, Free PMC Article
    2. A large-scale RNAi screen identifies functional classes of genes shaping synaptic development and maintenance. Valakh V, et al. Dev Biol, 2012 Jun 15. PMID 22542760, Free PMC Article
    3. Proteasome activity determines pupation timing through the degradation speed of timer molecule Blimp-1. Aly H, et al. Dev Growth Differ, 2018 Oct. PMID 30368781
    4. CHIP modulates APP-induced autophagy-dependent pathological symptoms in Drosophila. Zhuang L, et al. Aging Cell, 2020 Feb. PMID 31777182, Free PMC Article
    5. Phospholipid scramblase 1: an essential component of the nephrocyte slit diaphragm. Castillo-Mancho V, et al. Cell Mol Life Sci, 2024 Jun 15. PMID 38878170, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables peptidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, beta-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proteasome beta3 subunit
    Names
    20S proteasome beta3 subunit
    20s proteasome
    CG11981-PA
    Prosbeta3-PA
    beta3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9005313..9006226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141601.2 → NP_649858.1  proteasome beta3 subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649858.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0APH4, Q9XYN7
      UniProtKB/TrEMBL
      C0MJU2
      Related
      FBpp0081488, FBtr0082010
      Conserved Domains (1) summary
      cd03759
      Location:6 → 201
      proteasome_beta_type_3; proteasome beta type-3 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XYN7.1 Q9XYN7

    Gene LinkOut

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