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    CG1299 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38496, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1299provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035501
    Locus tag
    Dmel_CG1299
    See related
    AllianceGenome:FB:FBgn0035501
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-SP18; cSP18; Dmel\CG1299; SP18
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in embryonic dorsal epidermis; embryonic/larval tracheal dorsal trunk; embryonic/larval tracheal section; seminal receptacle; and tracheal fusion cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1299 in Genome Data Viewer
    Location:
    64A8-64A8; 3-10 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4148696..4152473)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4148696..4152473)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Adipokinetic hormone Neighboring gene nab Neighboring gene masquerade

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila NAB (dNAB) is an orphan transcriptional co-repressor required for correct CNS and eye development. Clements M, et al. Dev Dyn, 2003 Jan. PMID 12508226
    2. Transcriptional profiling of the sperm storage organs of Drosophila melanogaster. Prokupek AM, et al. Insect Mol Biol, 2009 Aug. PMID 19453766
    3. Identification of downstream targets of the bone morphogenetic protein pathway in the Drosophila nervous system. Kim NC, et al. Dev Dyn, 2010 Sep. PMID 20652954
    4. Drosophila melanogaster clip-domain serine proteases: Structure, function and regulation. Veillard F, et al. Biochimie, 2016 Mar. PMID 26453810
    5. Comparative transcriptome analysis reveals a potential mechanism for host nutritional manipulation after parasitization by Leptopilina boulardi. Zhou S, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2021 Sep. PMID 34120097

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1299-PA
    CG1299-PB
    NP_001261406.1
    NP_647862.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4148696..4152473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139605.2 → NP_647862.1  uncharacterized protein Dmel_CG1299, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647862.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXG6, Q9VZH5
      Related
      FBpp0073071
      Conserved Domains (4) summary
      smart00680
      Location:37 → 93
      CLIP; Clip or disulphide knot domain
      smart00020
      Location:260 → 503
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:261 → 503
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam12032
      Location:164 → 216
      CLIP; Regulatory CLIP domain of proteinases

    2. NM_001274477.1 → NP_001261406.1  uncharacterized protein Dmel_CG1299, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261406.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHC2, Q8SXG6
      Conserved Domains (3) summary
      smart00020
      Location:191 → 434
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:192 → 434
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam12032
      Location:95 → 147
      CLIP; Regulatory CLIP domain of proteinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHC2 M9PHC2
    Q8SXG6 Q8SXG6
    Q9VZH5 Q9VZH5

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