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    pico pico [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33003, updated on 9-Dec-2024

    Summary

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    Official Symbol
    picoprovided by FlyBase
    Official Full Name
    picoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261811
    Locus tag
    Dmel_CG11940
    See related
    AllianceGenome:FB:FBgn0261811
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LP01106; CG11940; Dmel\CG11940; Grb10; jog; Pico; RIAM30
    Summary
    Enables protein domain specific binding activity and protein phosphatase 1 binding activity. Involved in several processes, including actin filament organization; positive regulation of cell division; and positive regulation of filopodium assembly. Colocalizes with filopodium tip. Orthologous to several human genes including RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pico in Genome Data Viewer
    Location:
    18F2-18F4; 1-64 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19830215..19852059, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19724248..19746092, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene SKP1-related C Neighboring gene SKP1-related E Neighboring gene Nucleoporin 205kD Neighboring gene THADA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Validating RNAi phenotypes in Drosophila using a synthetic RNAi-resistant transgene. Jonchere V, et al. PLoS One, 2013. PMID 23950943, Free PMC Article
    2. The MRL proteins: adapting cell adhesion, migration and growth. Coló GP, et al. Eur J Cell Biol, 2012 Nov-Dec. PMID 22555291
    3. Mal/SRF is dispensable for cell proliferation in Drosophila. Thompson BJ. PLoS One, 2010 Apr 9. PMID 20404916, Free PMC Article
    4. Talin autoinhibition is required for morphogenesis. Ellis SJ, et al. Curr Biol, 2013 Sep 23. PMID 24012314, Free PMC Article
    5. Drosophila Gyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis. Kim M, et al. Autophagy, 2015. PMID 26086452, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lpd's Drosophila melanogaster orthologue Pico binds Scar, and both regulate collective epithelial border cell migration.
      Title: Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo.
    2. Phylogenetic analysis has shown that pico (CG11940) encodes the only member of the MRL family of proteins in Drosophila and pico is required for tissue and organismal growth.
      Title: Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of filopodium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with filopodium tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pico
    Names
    CG11940-PA
    CG11940-PB
    CG11940-PC
    CG11940-PD
    john glenn
    pico-PA
    pico-PB
    pico-PC
    pico-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19830215..19852059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167686.3 → NP_728307.1  pico, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728307.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQW0
      Related
      FBpp0074574
      Conserved Domains (3) summary
      cd01787
      Location:236 → 323
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd01259
      Location:361 → 486
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam00169
      Location:366 → 477
      PH; PH domain

    2. NM_134519.3 → NP_608363.1  pico, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608363.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWB7
      Related
      FBpp0074573
      Conserved Domains (3) summary
      cd01787
      Location:364 → 451
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd01259
      Location:489 → 614
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam00169
      Location:494 → 605
      PH; PH domain

    3. NM_001201745.1 → NP_001188674.1  pico, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188674.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSQ5
      Conserved Domains (3) summary
      cd01787
      Location:315 → 402
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd01259
      Location:440 → 565
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam00169
      Location:445 → 556
      PH; PH domain

    4. NM_001201746.1 → NP_001188675.1  pico, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188675.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQW0
      Conserved Domains (3) summary
      cd01787
      Location:236 → 323
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd01259
      Location:361 → 486
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam00169
      Location:366 → 477
      PH; PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MSQ5 M9MSQ5
    Q8IQW0 Q8IQW0
    Q8SZH0 Q8SZH0
    Q9VWB7 Q9VWB7

    Gene LinkOut

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