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    p115 p115 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31698, updated on 9-Dec-2024

    Summary

    Official Symbol
    p115provided by FlyBase
    Official Full Name
    p115provided by FlyBase
    Primary source
    FLYBASE:FBgn0040087
    Locus tag
    Dmel_CG1422
    See related
    AllianceGenome:FB:FBgn0040087
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1422; Dmel\CG1422; dp115; l(1)G0306
    Summary
    Involved in several processes, including male germ-line stem cell population maintenance; positive regulation of receptor signaling pathway via JAK-STAT; and regulation of imaginal disc-derived wing size. Located in Golgi stack; cytosol; and endoplasmic reticulum. Is expressed in several structures, including adult head; anlage in statu nascendi; antennal anlage; embryonic/larval midgut primordium; and gut section. Orthologous to human USO1 (USO1 vesicle transport factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See p115 in Genome Data Viewer
    Location:
    7C2-7C2; 1-21 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7894031..7896991)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7788064..7791024)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Nek2 Neighboring gene NADH dehydrogenase (ubiquinone) MNLL subunit Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Ribosomal protein S6

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Golgi vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of imaginal disc-derived wing size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transcytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle fusion with Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in Golgi stack IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    p115
    Names
    CG1422-PA
    CG1422-PB
    p115-PA
    p115-PB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7894031..7896991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298063.1NP_001284992.1  p115, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284992.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NFR8, Q9W3N6
      Conserved Domains (2) summary
      pfam04869
      Location:354632
      Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
      pfam04871
      Location:690832
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
    2. NM_132189.3NP_572417.1  p115, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572417.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NFR8, Q9W3N6
      Related
      FBpp0071045
      Conserved Domains (2) summary
      pfam04869
      Location:354632
      Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
      pfam04871
      Location:690832
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region