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    Bptf bromodomain PHD finger transcription factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303617, updated on 27-Dec-2024

    Summary

    Official Symbol
    Bptfprovided by RGD
    Official Full Name
    bromodomain PHD finger transcription factorprovided by RGD
    Primary source
    RGD:1307039
    See related
    EnsemblRapid:ENSRNOG00000047296 AllianceGenome:RGD:1307039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Falz
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and methylated histone binding activity. Predicted to contribute to ATP-dependent activity, acting on DNA. Involved in cellular response to nerve growth factor stimulus. Located in cell body; dendrite; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Kaposi's sarcoma; alcohol dependence; and neurodevelopmental disorder with dysmorphic facies and distal limb anomalies. Orthologous to human BPTF (bromodomain PHD finger transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 186.8), Spleen (RPKM 143.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Bptf in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (92480007..92582485, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (91980279..92082731, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (95248573..95350162, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA arginine (anticodon CCG) 2 Neighboring gene similar to human chromosome 17 open reading frame 58 Neighboring gene uncharacterized LOC120095194 Neighboring gene U11 spliceosomal RNA Neighboring gene nucleolar protein 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NURF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NURF complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nucleosome-remodeling factor subunit BPTF
    Names
    fetal Alzheimer antigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127535.3NP_001121007.2  nucleosome-remodeling factor subunit BPTF

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZVH2
      Related
      ENSRNOP00000082906.2, ENSRNOT00000119473.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      92480007..92582485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269218.1XP_063125288.1  nucleosome-remodeling factor subunit BPTF isoform X13

      UniProtKB/TrEMBL
      A0A8I6ALT2
    2. XM_039087419.2XP_038943347.1  nucleosome-remodeling factor subunit BPTF isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZVH2
      Conserved Domains (8) summary
      cd05509
      Location:29903090
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:250309
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03169
      Location:574759
      PHA03169; hypothetical protein; Provisional
      cd15559
      Location:402444
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29282974
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:21342510
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:26422777
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:466534
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    3. XM_039087420.2XP_038943348.1  nucleosome-remodeling factor subunit BPTF isoform X6

      UniProtKB/TrEMBL
      A0A8I6GLB4
      Conserved Domains (7) summary
      cd05509
      Location:29893089
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:250309
      DDT; domain in different transcription and chromosome remodeling factors
      cd15559
      Location:402444
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29272973
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:21332509
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:26412776
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:466534
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    4. XM_039087415.2XP_038943343.1  nucleosome-remodeling factor subunit BPTF isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZVH2
      Conserved Domains (7) summary
      cd05509
      Location:30493149
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:250309
      DDT; domain in different transcription and chromosome remodeling factors
      cd15559
      Location:402444
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29873033
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:21932569
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:27012836
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:466534
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    5. XM_039087418.2XP_038943346.1  nucleosome-remodeling factor subunit BPTF isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZVH2
      Conserved Domains (8) summary
      cd05509
      Location:29923092
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:250309
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03169
      Location:574759
      PHA03169; hypothetical protein; Provisional
      cd15559
      Location:402444
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29302976
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:21942570
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:27022837
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:466534
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    6. XM_039087422.2XP_038943350.1  nucleosome-remodeling factor subunit BPTF isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZVH2
      Conserved Domains (8) summary
      cd05509
      Location:29923092
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:250309
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03169
      Location:574759
      PHA03169; hypothetical protein; Provisional
      cd15559
      Location:402444
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29302976
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:21942570
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:27022837
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:466534
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    7. XM_039087414.2XP_038943342.1  nucleosome-remodeling factor subunit BPTF isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVH2
      Conserved Domains (8) summary
      cd05509
      Location:30503150
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:250309
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03169
      Location:574759
      PHA03169; hypothetical protein; Provisional
      cd15559
      Location:402444
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29883034
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:21942570
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:27022837
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:466534
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    8. XM_039087416.2XP_038943344.1  nucleosome-remodeling factor subunit BPTF isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZVH2
      Conserved Domains (8) summary
      cd05509
      Location:30503150
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:250309
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03169
      Location:574759
      PHA03169; hypothetical protein; Provisional
      cd15559
      Location:402444
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29883034
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:21942570
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:27022837
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:466534
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    9. XM_039087423.2XP_038943351.1  nucleosome-remodeling factor subunit BPTF isoform X9

      UniProtKB/TrEMBL
      A0A8I6ALT2
      Conserved Domains (7) summary
      cd05509
      Location:29233023
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:250309
      DDT; domain in different transcription and chromosome remodeling factors
      cd15559
      Location:402444
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:28612907
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:20672443
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:25752710
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:466534
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    10. XM_039087421.2XP_038943349.1  nucleosome-remodeling factor subunit BPTF isoform X7

      UniProtKB/TrEMBL
      A0A8I6ALT2
      Conserved Domains (8) summary
      cd05509
      Location:29843084
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:250309
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03169
      Location:574713
      PHA03169; hypothetical protein; Provisional
      cd15559
      Location:402444
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29222968
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:21282504
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:26362771
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:466534
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    11. XM_039087426.2XP_038943354.1  nucleosome-remodeling factor subunit BPTF isoform X18

      UniProtKB/TrEMBL
      A0A8I6ALT2
      Conserved Domains (7) summary
      cd05509
      Location:28112911
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:250309
      DDT; domain in different transcription and chromosome remodeling factors
      cd15559
      Location:402444
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:27492795
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:19082389
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:25212656
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:466534
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    12. XM_039087425.2XP_038943353.1  nucleosome-remodeling factor subunit BPTF isoform X15

      UniProtKB/TrEMBL
      A6HK68
      Conserved Domains (8) summary
      cd05509
      Location:28512951
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:250309
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03169
      Location:574759
      PHA03169; hypothetical protein; Provisional
      cd15559
      Location:402444
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:27892835
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:22602569
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:25832699
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:466534
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    13. XM_063269221.1XP_063125291.1  nucleosome-remodeling factor subunit BPTF isoform X17

      UniProtKB/TrEMBL
      A6HK68
    14. XM_039087424.2XP_038943352.1  nucleosome-remodeling factor subunit BPTF isoform X10

      UniProtKB/TrEMBL
      A0A0G2K7N8
      Related
      ENSRNOP00000088218.2, ENSRNOT00000104873.2
      Conserved Domains (8) summary
      cd05509
      Location:29093009
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:250309
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03169
      Location:574759
      PHA03169; hypothetical protein; Provisional
      cd15559
      Location:402444
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:28472893
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:22602569
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:25832699
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:466534
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    15. XM_063269216.1XP_063125286.1  nucleosome-remodeling factor subunit BPTF isoform X11

      UniProtKB/TrEMBL
      A0A0G2K7N8
    16. XM_063269217.1XP_063125287.1  nucleosome-remodeling factor subunit BPTF isoform X12

      UniProtKB/TrEMBL
      A0A8I6ALT2
      Related
      ENSRNOP00000094284.2, ENSRNOT00000104176.2
    17. XM_039087427.2XP_038943355.1  nucleosome-remodeling factor subunit BPTF isoform X20

      UniProtKB/TrEMBL
      A0A0G2K7N8
      Conserved Domains (7) summary
      cd05509
      Location:26702770
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:250309
      DDT; domain in different transcription and chromosome remodeling factors
      cd15559
      Location:402444
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:26082654
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:20792388
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:24022518
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:466534
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    18. XM_039087428.2XP_038943356.1  nucleosome-remodeling factor subunit BPTF isoform X19

      UniProtKB/TrEMBL
      A0A0G2K7N8
      Conserved Domains (8) summary
      cd05509
      Location:27972897
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      smart00571
      Location:250309
      DDT; domain in different transcription and chromosome remodeling factors
      PHA03169
      Location:574759
      PHA03169; hypothetical protein; Provisional
      cd15559
      Location:402444
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:27352781
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam03157
      Location:22062515
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam13868
      Location:25292645
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:466534
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    19. XM_063269219.1XP_063125289.1  nucleosome-remodeling factor subunit BPTF isoform X14

      UniProtKB/TrEMBL
      A0A0G2K7N8
    20. XM_063269220.1XP_063125290.1  nucleosome-remodeling factor subunit BPTF isoform X16

      UniProtKB/TrEMBL
      A0A0G2K7N8