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    Areg amphiregulin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29183, updated on 4-Jan-2025

    Summary

    Official Symbol
    Aregprovided by RGD
    Official Full Name
    amphiregulinprovided by RGD
    Primary source
    RGD:2149
    See related
    EnsemblRapid:ENSRNOG00000002754 AllianceGenome:RGD:2149
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in several processes, including negative regulation of osteoblast differentiation; neurogenesis; and response to hydrogen peroxide. Located in extracellular space. Used to study high grade glioma. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human AREG (amphiregulin). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 20.5), Lung (RPKM 3.7) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Areg in Genome Data Viewer
    Location:
    14p22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (17256384..17265641, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (16972185..16981443, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (18521921..18531179, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene betacellulin Neighboring gene epiregulin Neighboring gene epithelial mitogen

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity  
    enables epidermal growth factor receptor binding  
    enables epidermal growth factor receptor binding PubMed 
    enables growth factor activity  
    enables growth factor activity PubMed 
    enables receptor ligand activity  
    enables transmembrane receptor protein tyrosine kinase activator activity  
    Process Evidence Code Pubs
    involved_in ERBB2-EGFR signaling pathway  
    involved_in G protein-coupled receptor signaling pathway  
    acts_upstream_of_or_within dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway PubMed 
    involved_in epidermal growth factor receptor signaling pathway  
    acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation  
    involved_in glial cell proliferation PubMed 
    acts_upstream_of_or_within mammary gland alveolus development  
    acts_upstream_of_or_within mammary gland branching involved in thelarche  
    involved_in negative regulation of osteoblast differentiation PubMed 
    involved_in neuron projection development PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of phosphorylation PubMed 
    involved_in response to cAMP PubMed 
    acts_upstream_of_or_within response to estradiol  
    involved_in response to glucocorticoid PubMed 
    involved_in response to hydrogen peroxide PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to peptide hormone PubMed 
    Component Evidence Code Pubs
    located_in cell surface  
    located_in cytoplasm  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    is_active_in extracellular space  
    located_in extracellular space  
    located_in membrane  
    located_in nucleus  

    General protein information

    Preferred Names
    amphiregulin
    Names
    AR
    SDGF
    schwannoma-derived growth factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017123.2NP_058819.1  amphiregulin preproprotein

      See identical proteins and their annotated locations for NP_058819.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P24338
      UniProtKB/TrEMBL
      A6KKC9
      Related
      ENSRNOP00000003703.2, ENSRNOT00000003703.6
      Conserved Domains (1) summary
      PHA02887
      Location:137177
      PHA02887; EGF-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      17256384..17265641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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