Cdkn1a cyclin dependent kinase inhibitor 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdkn1aprovided by MGI
Official Full Name: cyclin dependent kinase inhibitor 1Aprovided by MGI
Primary source: MGI:MGI:104556
See related: Ensembl:ENSMUSG00000023067 AllianceGenome:MGI:104556
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P21; CDKI; CIP1; SDI1; Waf1; mda6; CAP20; Cdkn1; p21WAF; p21Cip1
Summary: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at the G1 pahse. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression: Broad expression in stomach adult (RPKM 65.8), large intestine adult (RPKM 63.7) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 15.12 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (29309953..29319696)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (29090979..29100722)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Essential role of p21[Waf1/Cip1] in the modulation of post-traumatic hippocampal Neural Stem Cells response.
Title: Essential role of p21(Waf1/Cip1) in the modulation of post-traumatic hippocampal Neural Stem Cells response.
Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair.
Title: Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair.
Absence of E2f1 Negates Pro-osteogenic Impacts of p21 Absence.
Title: Absence of E2f1 Negates Pro-osteogenic Impacts of p21 Absence.
Kielin/chordin-like protein deficiency aggravates pressure overload-induced cardiac dysfunction and remodeling via P53/P21/CCNB1 signaling in mice.
Title: Kielin/chordin-like protein deficiency aggravates pressure overload-induced cardiac dysfunction and remodeling via P53/P21/CCNB1 signaling in mice.
High fat diet-induced downregulation of TRPV2 mediates hepatic steatosis via p21 signalling.
Title: High fat diet-induced downregulation of TRPV2 mediates hepatic steatosis via p21 signalling.
Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice.
Title: Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice.
p21 Prevents the Exhaustion of CD4[+] T Cells Within the Antitumor Immune Response Against Colorectal Cancer.
Title: p21 Prevents the Exhaustion of CD4(+) T Cells Within the Antitumor Immune Response Against Colorectal Cancer.
P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.
Title: P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.
Elevated CDKN1A (P21) mediates beta-thalassemia erythroid apoptosis, but its loss does not improve beta-thalassemic erythropoiesis.
Title: Elevated CDKN1A (P21) mediates β-thalassemia erythroid apoptosis, but its loss does not improve β-thalassemic erythropoiesis.
P21 facilitates macrophage chemotaxis by promoting CCL7 in the lung epithelial cell lines treated with radiation and bleomycin.
Title: P21 facilitates macrophage chemotaxis by promoting CCL7 in the lung epithelial cell lines treated with radiation and bleomycin.

Submit: New GeneRIF Correction See all GeneRIFs (433)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (16) 1 citation
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC169986P1 (e-PCR)
- UniSTS:271618

NoName (e-PCR)
- UniSTS:548375

PMC133542P4 (e-PCR)
- UniSTS:270628

PMC133542P5 (e-PCR)
- UniSTS:270629

NoName (e-PCR)
- UniSTS:548145

PMC316389P1 (e-PCR)
- UniSTS:272978

NoName (e-PCR)
- UniSTS:548208

Cdkn1a (e-PCR), detects polymorphism
- UniSTS:531071

Cdkn1a (e-PCR), detects polymorphism
- UniSTS:461955

PMC125030P1 (e-PCR)
- UniSTS:270480

PMC125257P1 (e-PCR)
- UniSTS:270486

Cdkn1a (e-PCR), detects polymorphism
- UniSTS:525209

AW048937 (e-PCR)
- UniSTS:166043

Cdkn1a (e-PCR), detects polymorphism
- UniSTS:525477

PMC149170P1 (e-PCR)
- UniSTS:271028

PMC126040P2 (e-PCR)
- UniSTS:270520

PMC126110P1 (e-PCR)
- UniSTS:270529

PMC307617P2 (e-PCR)
- UniSTS:272581

PMC262691P4 (e-PCR)
- UniSTS:272326

PMC31865P1 (e-PCR)
- UniSTS:273094

PMC114802P2 (e-PCR)
- UniSTS:270280

Cdkn1a (e-PCR), detects polymorphism
- UniSTS:548056

PMC150726P2 (e-PCR)
- UniSTS:271074

Cdkn1a (e-PCR), detects polymorphism
- UniSTS:547812

Cdkn1a (e-PCR), detects polymorphism
- UniSTS:141308

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin binding	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein kinase activating kinase activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein kinase activating kinase activity	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein sequestering activity	IEA Inferred from Electronic Annotation more info
enables protein sequestering activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in animal organ regeneration	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV-B	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to amino acid starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to gamma radiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to heat	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular senescence	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epidermis development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fibroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intestinal epithelial cell maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within keratinocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within keratinocyte proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic G2 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cyclin-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oncogene-induced cell senescence	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within oncogene-induced cell senescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of B cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle G1/S phase transition	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of cyclin-dependent protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to X-ray	IEA Inferred from Electronic Annotation more info
involved_in response to aldosterone	IEA Inferred from Electronic Annotation more info
involved_in response to arsenic-containing substance	IEA Inferred from Electronic Annotation more info
involved_in response to corticosterone	IEA Inferred from Electronic Annotation more info
involved_in response to hyperoxia	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of PCNA-p21 complex	ISO Inferred from Sequence Orthology more info
part_of PCNA-p21 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin-dependent protein kinase holoenzyme complex	IPI Inferred from Physical Interaction more info	PubMed
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: cyclin-dependent kinase inhibitor 1

Names: CDK-interacting protein 1; melanoma differentiation-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111099.2 → NP_001104569.1 cyclin-dependent kinase inhibitor 1

See identical proteins and their annotated locations for NP_001104569.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC167363, AK007630, AK149910, BY206886

Consensus CDS

CCDS28591.1

UniProtKB/Swiss-Prot

P39689

UniProtKB/TrEMBL

Q4FK34, Q564P6

Related

ENSMUSP00000113150.2, ENSMUST00000119901.9

Conserved Domains (1) summary

pfam02234
Location:19 → 62

CDI; Cyclin-dependent kinase inhibitor
NM_007669.5 → NP_031695.1 cyclin-dependent kinase inhibitor 1

See identical proteins and their annotated locations for NP_031695.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC167363, AK007630, AK149910

Consensus CDS

CCDS28591.1

UniProtKB/Swiss-Prot

P39689

UniProtKB/TrEMBL

Q4FK34, Q564P6

Related

ENSMUSP00000023829.7, ENSMUST00000023829.8

Conserved Domains (1) summary

pfam02234
Location:19 → 62

CDI; Cyclin-dependent kinase inhibitor