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    fmo-3 Flavin-containing monooxygenase [ Caenorhabditis elegans ]

    Gene ID: 176491, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fmo-3
    Official Full Name
    Flavin-containing monooxygenase
    Primary source
    WormBase:WBGene00001478
    Locus tag
    CELE_Y39A1A.19
    See related
    AllianceGenome:WB:WBGene00001478
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable monooxygenase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to several human genes including FMO2 (flavin containing dimethylaniline monoxygenase 2); FMO3 (flavin containing dimethylaniline monoxygenase 3); and FMO4 (flavin containing dimethylaniline monoxygenase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fmo-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (10694681..10698861)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Leucine rich repeat protein Neighboring gene BHLH domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ATP synthase subunit C lysine N-methyltransferase Neighboring gene Xenotropic and polytropic retrovirus receptor 1 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The fmo genes of Caenorhabditis elegans and C. briggsae: characterisation, gene expression and comparative genomic analysis. Petalcorin MI, et al. Gene, 2005 Feb 14. PMID 15716098
    2. Flavin monooxygenases regulate Caenorhabditis elegans axon guidance and growth cone protrusion with UNC-6/Netrin signaling and Rac GTPases. Gujar MR, et al. PLoS Genet, 2017 Aug. PMID 28859089, Free PMC Article
    3. Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP-mediated feedforward loop. Lee Y, et al. J Cell Biol, 2021 May 3. PMID 33666644, Free PMC Article
    4. Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans. Gaeta AL, et al. PLoS Genet, 2022 Aug. PMID 35984862, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables N,N-dimethylaniline monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD(P)H oxidase H2O2-forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH oxidase H202-forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hypotaurine monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Flavin-containing monooxygenase
    NP_001380215.1
    • Confirmed by transcript evidence
    NP_499356.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10694681..10698861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066955.7 → NP_499356.1  Flavin-containing monooxygenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499356.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECJ8
      Conserved Domains (2) summary
      pfam00743
      Location:5 → 495
      FMO-like; Flavin-binding monooxygenase-like
      cl21454
      Location:9 → 223
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001392204.1 → NP_001380215.1  Flavin-containing monooxygenase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RC69
      Conserved Domains (1) summary
      pfam00743
      Location:2 → 438
      FMO-like; Flavin-binding monooxygenase-like
    Nucleotide Protein
    Heading Accession and Version

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